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Sirpa signal-regulatory protein alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 25528, updated on 19-Apr-2019

Summary

Official Symbol
Sirpaprovided by RGD
Official Full Name
signal-regulatory protein alphaprovided by RGD
Primary source
RGD:3449
See related
Ensembl:ENSRNOG00000004763
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bit; Ptpns1; SHPS-1
Summary
plays a role in macrophage fusion [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 215.3), Brain (RPKM 133.4) and 8 other tissues See more

Genomic context

See Sirpa in Genome Data Viewer
Location:
3q36
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122113735..122152478)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (127864145..127902598, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene signal-regulatory protein beta 3 Neighboring gene uncharacterized LOC108350460 Neighboring gene uncharacterized LOC108350461 Neighboring gene uncharacterized LOC102546597 Neighboring gene uncharacterized LOC103691885 Neighboring gene prodynorphin Neighboring gene ribosomal protein L22-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTPase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein antigen binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in heterotypic cell-cell adhesion IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylated amino acid binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization ISO
Inferred from Sequence Orthology
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interferon-gamma IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interleukin-12 ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
PubMed 
granulocyte migration ISO
Inferred from Sequence Orthology
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
monocyte extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of chemokine (C-C motif) ligand 5 production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of macrophage inflammatory protein 1 alpha production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
PubMed 
phagocytosis, recognition ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type substrate 1
Names
Brain immunoglobulin like protein with tyrosine - based activation motifs
CD172 antigen-like family member A
Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)
SHP substrate 1
brain Ig-like molecule with tyrosine-based activation motifs
inhibitory receptor SHPS-1
macrophage fusion receptor
macrophage membrane protein MFP150
signal-regulatory protein alpha-1
sirp-alpha-1
NP_037148.2
XP_006235013.1
XP_006235014.1
XP_006235015.1
XP_017446985.1
XP_017446986.1
XP_017446987.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013016.2NP_037148.2  tyrosine-protein phosphatase non-receptor type substrate 1 precursor

    See identical proteins and their annotated locations for NP_037148.2

    Status: PROVISIONAL

    Source sequence(s)
    U62328
    UniProtKB/Swiss-Prot
    P97710
    Related
    ENSRNOP00000006408.6, ENSRNOT00000006408.6
    Conserved Domains (4) summary
    cd00098
    Location:266344
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41146
    IG_like; Immunoglobulin like
    pfam07686
    Location:38147
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:146255
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    122113735..122152478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591498.1XP_017446987.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    UniProtKB/TrEMBL
    Q499T3
    Conserved Domains (4) summary
    cd00098
    Location:266344
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41146
    IG_like; Immunoglobulin like
    pfam07686
    Location:38147
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:146255
    Ig; Immunoglobulin domain
  2. XM_006234953.3XP_006235015.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    See identical proteins and their annotated locations for XP_006235015.1

    UniProtKB/TrEMBL
    Q499T3
    Conserved Domains (4) summary
    cd00098
    Location:266344
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41146
    IG_like; Immunoglobulin like
    pfam07686
    Location:38147
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:146255
    Ig; Immunoglobulin domain
  3. XM_017591496.1XP_017446985.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    UniProtKB/TrEMBL
    Q499T3
    Conserved Domains (4) summary
    cd00098
    Location:266344
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41146
    IG_like; Immunoglobulin like
    pfam07686
    Location:38147
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:146255
    Ig; Immunoglobulin domain
  4. XM_006234952.3XP_006235014.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    See identical proteins and their annotated locations for XP_006235014.1

    UniProtKB/TrEMBL
    Q499T3
    Related
    ENSRNOP00000069024.1, ENSRNOT00000091935.1
    Conserved Domains (4) summary
    cd00098
    Location:266344
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41146
    IG_like; Immunoglobulin like
    pfam07686
    Location:38147
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:146255
    Ig; Immunoglobulin domain
  5. XM_017591497.1XP_017446986.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

    UniProtKB/Swiss-Prot
    P97710
    Conserved Domains (4) summary
    cd00098
    Location:266344
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41146
    IG_like; Immunoglobulin like
    pfam07686
    Location:38147
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:146255
    Ig; Immunoglobulin domain
  6. XM_006234951.3XP_006235013.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    See identical proteins and their annotated locations for XP_006235013.1

    UniProtKB/TrEMBL
    Q499T3
    Conserved Domains (4) summary
    cd00098
    Location:266344
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41146
    IG_like; Immunoglobulin like
    pfam07686
    Location:38147
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:146255
    Ig; Immunoglobulin domain

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    115635887..115673609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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