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MYADML2 myeloid associated differentiation marker like 2 [ Homo sapiens (human) ]

Gene ID: 255275, updated on 22-Sep-2022

Summary

Official Symbol
MYADML2provided by HGNC
Official Full Name
myeloid associated differentiation marker like 2provided by HGNC
Primary source
HGNC:HGNC:34548
See related
Ensembl:ENSG00000185105 AllianceGenome:HGNC:34548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MYADML2 in Genome Data Viewer
Location:
17q25.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81939645..81947233, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82806804..82814392, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79897521..79905109, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MAF bZIP transcription factor G Neighboring gene MYC inducible lncRNA inactivating p53 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene notum, palmitoleoyl-protein carboxylesterase Neighboring gene uncharacterized LOC124904087 Neighboring gene uncharacterized LOC105371939

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of myeloid-associated differentiation marker-like 2 (MYADML2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myeloid-associated differentiation marker-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145113.3NP_001138585.2  myeloid-associated differentiation marker-like protein 2

    See identical proteins and their annotated locations for NP_001138585.2

    Status: VALIDATED

    Source sequence(s)
    AC145207, BC029306, BM674638
    Consensus CDS
    CCDS45815.1
    UniProtKB/Swiss-Prot
    A6NDP7
    Related
    ENSP00000386702.2, ENST00000409745.2
    Conserved Domains (1) summary
    pfam01284
    Location:159297
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81939645..81947233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82806804..82814392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)