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Ptgis prostaglandin I2 synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25527, updated on 13-Aug-2019

Summary

Official Symbol
Ptgisprovided by RGD
Official Full Name
prostaglandin I2 synthaseprovided by RGD
Primary source
RGD:3438
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PGIS
Summary
catalyzes the conversion of prostaglandin H2 to prostacyclin in prostaglandin biosynthesis [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Expression
Biased expression in Heart (RPKM 131.7), Uterus (RPKM 125.7) and 6 other tissues See more
Orthologs

Genomic context

See Ptgis in Genome Data Viewer
Location:
3q42
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (163950746..163986129, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (170109317..170143882, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene zinc finger, NFX1-type containing 1 Neighboring gene uncharacterized LOC100911177 Neighboring gene potassium voltage-gated channel subfamily B member 1 Neighboring gene uncharacterized LOC102552303 Neighboring gene similar to 60S ribosomal protein L38 Neighboring gene beta-1,4-galactosyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding ISO
Inferred from Sequence Orthology
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-I synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin-I synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-I synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin-I synthase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to interleukin-1 ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to interleukin-6 ISS
Inferred from Sequence or Structural Similarity
more info
 
decidualization ISO
Inferred from Sequence Orthology
more info
PubMed 
embryo implantation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood vessel diameter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
caveola ISO
Inferred from Sequence Orthology
more info
PubMed 
caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
prostacyclin synthase
Names
prostaglandin I2 (prostacyclin) synthase
NP_113745.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031557.2NP_113745.1  prostacyclin synthase precursor

    See identical proteins and their annotated locations for NP_113745.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061814
    UniProtKB/Swiss-Prot
    Q62969
    Conserved Domains (1) summary
    cl12078
    Location:28490
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    163950746..163986129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    154508773..154544997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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