Format

Send to:

Choose Destination

Ptgds prostaglandin D2 synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25526, updated on 18-Apr-2019

Summary

Official Symbol
Ptgdsprovided by RGD
Official Full Name
prostaglandin D2 synthaseprovided by RGD
Primary source
RGD:3433
See related
Ensembl:ENSRNOG00000015550
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PH2DISO
Summary
catalyzes conversion of prostaglandin H2 to prostaglandin D2, a major prostaglandin that mediates sleep, body temperature, hormone release, and odor responses [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 3126.9) See more
Orthologs

Genomic context

See Ptgds in Genome Data Viewer
Location:
3p13
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2686125..2689059, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (2667538..2670472, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691748 Neighboring gene chloride intracellular channel 3 Neighboring gene PAXX, non-homologous end joining factor Neighboring gene lipocalin 12 Neighboring gene complement C8 gamma chain Neighboring gene F-box and WD repeat domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
fatty acid binding ISO
Inferred from Sequence Orthology
more info
PubMed 
prostaglandin-D synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-D synthase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
retinoid binding IDA
Inferred from Direct Assay
more info
PubMed 
retinoid binding ISO
Inferred from Sequence Orthology
more info
PubMed 
small molecule binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of male germ cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of male germ cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
nuclear envelope NAS
Non-traceable Author Statement
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
prostaglandin-H2 D-isomerase
Names
PGD2 synthase
PGDS
PGDS2
Prostaglandin D synthase
glutathione-independent PGD synthase
glutathione-independent PGD synthetase
lipocalin-type prostaglandin-D synthase
prostaglandin D2 synthase (brain)
NP_037147.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013015.2NP_037147.1  prostaglandin-H2 D-isomerase precursor

    See identical proteins and their annotated locations for NP_037147.1

    Status: PROVISIONAL

    Source sequence(s)
    J04488
    UniProtKB/Swiss-Prot
    P22057
    Related
    ENSRNOP00000020926.4, ENSRNOT00000020926.5
    Conserved Domains (1) summary
    pfam00061
    Location:40182
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    2686125..2689059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    3107001..3109935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center