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LRRC57 leucine rich repeat containing 57 [ Homo sapiens (human) ]

Gene ID: 255252, updated on 3-Dec-2022

Summary

Official Symbol
LRRC57provided by HGNC
Official Full Name
leucine rich repeat containing 57provided by HGNC
Primary source
HGNC:HGNC:26719
See related
Ensembl:ENSG00000180979 AllianceGenome:HGNC:26719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 9.0), placenta (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See LRRC57 in Genome Data Viewer
Location:
15q15.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (42528327..42548793, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40343873..40354843, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42830027..42840991, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene calpain 3 Neighboring gene uncharacterized LOC105370794 Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene synaptosome associated protein 23 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene MYL12B pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36812, DKFZp686H1865

General protein information

Preferred Names
leucine-rich repeat-containing protein 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153260.3NP_694992.2  leucine-rich repeat-containing protein 57

    See identical proteins and their annotated locations for NP_694992.2

    Status: VALIDATED

    Source sequence(s)
    AC018362, AK094891, BE301068, BQ130124, CN350663, DA749946
    Consensus CDS
    CCDS10089.1
    UniProtKB/Swiss-Prot
    Q8N1T6, Q8N9N7
    UniProtKB/TrEMBL
    A0A024R9M3
    Related
    ENSP00000380319.3, ENST00000397130.8
    Conserved Domains (2) summary
    PRK15370
    Location:21211
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:4063
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    42528327..42548793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521423.4XP_011519725.1  leucine-rich repeat-containing protein 57 isoform X1

    Related
    ENSP00000497618.1, ENST00000650210.1
    Conserved Domains (3) summary
    cd00116
    Location:37191
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4063
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:3897
    LRR_8; Leucine rich repeat
  2. XM_011521424.4XP_011519726.1  leucine-rich repeat-containing protein 57 isoform X2

    Conserved Domains (3) summary
    cd00116
    Location:37191
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4063
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:3897
    LRR_8; Leucine rich repeat
  3. XM_047432335.1XP_047288291.1  leucine-rich repeat-containing protein 57 isoform X3

    UniProtKB/Swiss-Prot
    Q8N1T6
    UniProtKB/TrEMBL
    A0A024R9M3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    40343873..40354843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)