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LRRC57 leucine rich repeat containing 57 [ Homo sapiens (human) ]

Gene ID: 255252, updated on 1-Jun-2020

Summary

Official Symbol
LRRC57provided by HGNC
Official Full Name
leucine rich repeat containing 57provided by HGNC
Primary source
HGNC:HGNC:26719
See related
Ensembl:ENSG00000180979 Ensembl:ENSG00000285942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 9.0), placenta (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See LRRC57 in Genome Data Viewer
Location:
15q15.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42528332..42548799, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42834720..42841002, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene calpain 3 Neighboring gene uncharacterized LOC105370794 Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene synaptosome associated protein 23 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene myosin light chain 12B pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36812, DKFZp686H1865

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular exosome HDA PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 57

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153260.3NP_694992.2  leucine-rich repeat-containing protein 57

    See identical proteins and their annotated locations for NP_694992.2

    Status: VALIDATED

    Source sequence(s)
    AC018362, AK094891, BE301068, BQ130124, CN350663, DA749946
    Consensus CDS
    CCDS10089.1
    UniProtKB/Swiss-Prot
    Q8N9N7
    UniProtKB/TrEMBL
    A0A024R9M3
    Related
    ENSP00000380319.3, ENST00000397130.8
    Conserved Domains (2) summary
    sd00033
    Location:4063
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:21211
    NEL; C-terminal novel E3 ligase, LRR-interacting

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42528332..42548799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521423.3XP_011519725.1  leucine-rich repeat-containing protein 57 isoform X1

    Related
    ENSP00000497618.1, ENST00000650210.1
    Conserved Domains (3) summary
    cd00116
    Location:37191
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4063
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:3897
    LRR_8; Leucine rich repeat
  2. XM_011521424.3XP_011519726.1  leucine-rich repeat-containing protein 57 isoform X2

    Conserved Domains (3) summary
    cd00116
    Location:37191
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4063
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:3897
    LRR_8; Leucine rich repeat
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