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Prkcz protein kinase C, zeta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25522, updated on 18-Sep-2024

Summary

Official Symbol
Prkczprovided by RGD
Official Full Name
protein kinase C, zetaprovided by RGD
Primary source
RGD:3399
See related
EnsemblRapid:ENSRNOG00000015480 AllianceGenome:RGD:3399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pkcz; r14-3-3; 14-3-3-zetaisoform
Summary
Enables several functions, including 14-3-3 protein binding activity; enzyme binding activity; and protein kinase C activity. Involved in several processes, including activation of phospholipase D activity; activation of protein kinase B activity; and positive regulation of cell communication. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and stress fiber. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 108.1), Kidney (RPKM 59.9) and 7 other tissues See more
Orthologs
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Genomic context

See Prkcz in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171101774..171212694, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165817786..165930386, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172658071..172769492, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692526 Neighboring gene FA core complex associated protein 20 Neighboring gene uncharacterized LOC134479059 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables potassium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of phospholipase D activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of protein kinase B activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-13 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-5 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon hillock ISO
Inferred from Sequence Orthology
more info
 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C zeta type
Names
nPKC-zeta
NP_071952.1
XP_006239598.1
XP_038965237.1
XP_038965239.1
XP_038965240.1
XP_063143261.1
XP_063143263.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429418.1NP_001416347.1  protein kinase C zeta type isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
  2. NM_001429421.1NP_001416350.1  protein kinase C zeta type isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
  3. NM_001429422.1NP_001416351.1  protein kinase C zeta type isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
  4. NM_001429423.1NP_001416352.1  protein kinase C zeta type isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IUP4
  5. NM_001429424.1NP_001416353.1  protein kinase C zeta type isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IUP4
  6. NM_022507.2NP_071952.1  protein kinase C zeta type isoform 2

    See identical proteins and their annotated locations for NP_071952.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P09217
    UniProtKB/TrEMBL
    A6IUP2
    Related
    ENSRNOP00000021285.5, ENSRNOT00000021285.8
    Conserved Domains (4) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    smart00220
    Location:252518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:131183
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:236592
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171101774..171212694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109309.2XP_038965237.1  protein kinase C zeta type isoform X1

    Related
    ENSRNOP00000108141.1, ENSRNOT00000132708.1
    Conserved Domains (3) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05617
    Location:249605
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cd21095
    Location:129183
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
  2. XM_006239536.5XP_006239598.1  protein kinase C zeta type isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  3. XM_039109312.2XP_038965240.1  protein kinase C zeta type isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:66422
    PKc_like; Protein Kinases, catalytic domain
  4. XM_063287193.1XP_063143263.1  protein kinase C zeta type isoform X4

  5. XM_063287191.1XP_063143261.1  protein kinase C zeta type isoform X3

  6. XM_039109311.2XP_038965239.1  protein kinase C zeta type isoform X2

    Conserved Domains (2) summary
    cd05617
    Location:141497
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cd21095
    Location:2175
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type