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Prkcz protein kinase C, zeta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25522, updated on 22-Nov-2020

Summary

Official Symbol
Prkczprovided by RGD
Official Full Name
protein kinase C, zetaprovided by RGD
Primary source
RGD:3399
See related
Ensembl:ENSRNOG00000015480
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pkcz; r14-3-3; 14-3-3-zetaisoform
Summary
may play an important role in insulin resistance in skeletal muscle and adipose tissue; mediates matrix metalloproteinase-9 (MMP-9) expression in glioma cells, key process in tumor invasion, through NF-kappaB [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 108.1), Kidney (RPKM 59.9) and 7 other tissues See more
Orthologs

Genomic context

See Prkcz in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172658071..172769492, complement)
106 current Rn_Celera (GCF_000002265.2) 5 AC_000073.1 (164023257..164132959, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (176116787..176228206, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692526 Neighboring gene FA core complex associated protein 20 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase subunit P-like Neighboring gene gamma-aminobutyric acid type A receptor subunit delta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of phospholipase D activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase B activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 2 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-10 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-13 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-5 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
apical cortex ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
axon hillock ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C zeta type
Names
nPKC-zeta
NP_071952.1
XP_006239597.1
XP_006239598.1
XP_008762559.1
XP_017448650.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022507.1NP_071952.1  protein kinase C zeta type

    See identical proteins and their annotated locations for NP_071952.1

    Status: PROVISIONAL

    Source sequence(s)
    J04532
    UniProtKB/Swiss-Prot
    P09217
    Related
    ENSRNOP00000021285.5, ENSRNOT00000021285.6
    Conserved Domains (4) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    smart00220
    Location:252518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:131183
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:236592
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    172658071..172769492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764337.2XP_008762559.1  protein kinase C zeta type isoform X2

    Conserved Domains (4) summary
    smart00220
    Location:206472
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:85137
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:152
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl21453
    Location:190546
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017593161.1XP_017448650.1  protein kinase C zeta type isoform X1

  3. XM_006239536.3XP_006239598.1  protein kinase C zeta type isoform X4

    See identical proteins and their annotated locations for XP_006239598.1

    Conserved Domains (1) summary
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006239535.3XP_006239597.1  protein kinase C zeta type isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:144410
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:2375
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:128484
    PKc_like; Protein Kinases, catalytic domain

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    164023257..164132959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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