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Prkcz protein kinase C, zeta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25522, updated on 12-Aug-2018

Summary

Official Symbol
Prkczprovided by RGD
Official Full Name
protein kinase C, zetaprovided by RGD
Primary source
RGD:3399
See related
Ensembl:ENSRNOG00000015480
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pkcz; r14-3-3; 14-3-3-zetaisoform
Summary
may play an important role in insulin resistance in skeletal muscle and adipose tissue; mediates matrix metalloproteinase-9 (MMP-9) expression in glioma cells, key process in tumor invasion, through NF-kappaB [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 108.1), Kidney (RPKM 59.9) and 7 other tissues See more
Orthologs

Genomic context

See Prkcz in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172658071..172769492, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (176116787..176228206, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692526 Neighboring gene FA core complex associated protein 20 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase subunit P-like Neighboring gene gamma-aminobutyric acid type A receptor delta subunit

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
  • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
    GPVI-mediated activation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • NFE2L2, organism-specific biosystem (from WikiPathways)
    NFE2L2, organism-specific biosystem
    NFE2L2
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
    Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
    Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
    TNF-alpha NF-kB Signaling Pathway
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated cell proliferation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of phospholipase D activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase B activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 2 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-10 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-10 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-13 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-13 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-5 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-5 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
PubMed 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
apical cortex IEA
Inferred from Electronic Annotation
more info
 
apical cortex ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
axon hillock IEA
Inferred from Electronic Annotation
more info
 
axon hillock ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C zeta type
Names
14 - 3 - 3 - zeta isoform
nPKC-zeta
NP_071952.1
XP_006239597.1
XP_006239598.1
XP_008762559.1
XP_017448650.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022507.1NP_071952.1  protein kinase C zeta type

    See identical proteins and their annotated locations for NP_071952.1

    Status: PROVISIONAL

    Source sequence(s)
    J04532
    UniProtKB/Swiss-Prot
    P09217
    Related
    ENSRNOP00000021285.5, ENSRNOT00000021285.6
    Conserved Domains (4) summary
    cd06404
    Location:1698
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    smart00220
    Location:252518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:131183
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:236592
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    172658071..172769492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764337.2XP_008762559.1  protein kinase C zeta type isoform X2

    Conserved Domains (4) summary
    smart00220
    Location:206472
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:85137
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:152
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl21453
    Location:190546
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017593161.1XP_017448650.1  protein kinase C zeta type isoform X1

  3. XM_006239536.3XP_006239598.1  protein kinase C zeta type isoform X4

    See identical proteins and their annotated locations for XP_006239598.1

    Conserved Domains (2) summary
    smart00220
    Location:69335
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:53409
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006239535.3XP_006239597.1  protein kinase C zeta type isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:144410
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:2375
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:128484
    PKc_like; Protein Kinases, catalytic domain

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    164023257..164132959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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