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PLA2G4F phospholipase A2 group IVF [ Homo sapiens (human) ]

Gene ID: 255189, updated on 4-Oct-2020

Summary

Official Symbol
PLA2G4Fprovided by HGNC
Official Full Name
phospholipase A2 group IVFprovided by HGNC
Primary source
HGNC:HGNC:27396
See related
Ensembl:ENSG00000168907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLA2G4FZ
Expression
Biased expression in skin (RPKM 54.3), lung (RPKM 12.6) and 6 other tissues See more
Orthologs

Genomic context

See PLA2G4F in Genome Data Viewer
Location:
15q15.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42139034..42156636, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42433332..42448839, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IVE Neighboring gene uncharacterized LOC105370793 Neighboring gene phospholipase A2 group IVD Neighboring gene VPS39 subunit of HOPS complex Neighboring gene uncharacterized LOC105370795 Neighboring gene microRNA 627 Neighboring gene transmembrane protein 87A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp666G192, DKFZp781B229

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
cellular response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytosolic phospholipase A2 zeta
Names
cPLA2-zeta
NP_998765.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213600.4NP_998765.3  cytosolic phospholipase A2 zeta precursor

    See identical proteins and their annotated locations for NP_998765.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC036103, AK172836, BC142682
    Consensus CDS
    CCDS32204.1
    UniProtKB/Swiss-Prot
    Q68DD2
    UniProtKB/TrEMBL
    A5PKZ7
    Related
    ENSP00000380442.4, ENST00000397272.7
    Conserved Domains (3) summary
    cd07201
    Location:303845
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:46163
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:295791
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit

RNA

  1. NR_033151.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC036103, AK172836, BC035335

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42139034..42156636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_931785.1 RNA Sequence

  2. XR_931786.1 RNA Sequence

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