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Pou1f1 POU class 1 homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25517, updated on 2-Oct-2018

Summary

Official Symbol
Pou1f1provided by RGD
Official Full Name
POU class 1 homeobox 1provided by RGD
Primary source
RGD:3367
See related
Ensembl:ENSRNOG00000000715
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GHF1; Pit1; GHF1A; PIT1Z
Summary
pituitary-specific transcription factor that activates expression of the GH and PRL genes [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 2.5), Kidney (RPKM 2.4) and 9 other tissues See more
Orthologs

Genomic context

See Pou1f1 in Genome Data Viewer
Location:
11p12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (2645659..2662581)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (2630048..2647084)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 1F Neighboring gene geminin-like Neighboring gene charged multivesicular body protein 2B Neighboring gene similar to histone deacetylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cell fate specification ISO
Inferred from Sequence Orthology
more info
 
determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
 
determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inositol trisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
somatotropin secreting cell development IEA
Inferred from Electronic Annotation
more info
 
somatotropin secreting cell development ISO
Inferred from Sequence Orthology
more info
 
somatotropin secreting cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pituitary-specific positive transcription factor 1
Names
GHF-1
POU domain, class 1, transcription factor 1
Pituary specific transcription factor 1 (growth hormone factor 1)
growth hormone factor 1
homeodomain protein for Growth Hormone (GH)
pit-1
pituitary-specific positive transcription factor 1 variant w

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013008.3NP_037140.2  pituitary-specific positive transcription factor 1

    See identical proteins and their annotated locations for NP_037140.2

    Status: PROVISIONAL

    Source sequence(s)
    BC061563
    UniProtKB/TrEMBL
    Q6P7Q8
    Related
    ENSRNOP00000000905.5, ENSRNOT00000000905.6
    Conserved Domains (2) summary
    smart00352
    Location:124198
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:217270
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    2645659..2662581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247974.1XP_006248036.1  pituitary-specific positive transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006248036.1

    UniProtKB/Swiss-Prot
    P10037
    Conserved Domains (2) summary
    smart00352
    Location:150224
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:243296
    Homeobox; Homeobox domain

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    3294195..3311824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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