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Pnoc prepronociceptin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25516, updated on 30-Jul-2025
Official Symbol
Pnocprovided by RGD
Official Full Name
prepronociceptinprovided by RGD
Primary source
RGD:3362
See related
Ensembl:ENSRNOG00000014231 AllianceGenome:RGD:3362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
N23K; Npnc1
Summary
Predicted to enable opioid receptor binding activity and receptor ligand activity. Involved in chemical synaptic transmission; female pregnancy; and neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; neuronal cell body; and synaptic membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in neonatal abstinence syndrome. Orthologous to human PNOC (prepronociceptin). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Uterus (RPKM 75.9), Brain (RPKM 26.2) and 2 other tissues See more
Orthologs
human mouse all
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See Pnoc in Genome Data Viewer
Location:
15p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43800240..43827841, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39624635..39652463, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48805841..48833071, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097019 Neighboring gene zinc finger protein 395 Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene annexin A2, pseudogene 1 Neighboring gene ribosomal protein S17, pseudogene 14

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Peripheral mechanisms involved in gastric mucosal protection by intracerebroventricular and intraperitoneal nociceptin in rats. Polidori C, et al. Endocrinology, 2005 Sep. PMID 15919744
  2. [Effects of acute hypobaric hypoxia on spatial learning, memory and its relationship with orphanin FQ of hippocampus in rats]. Lin JX, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2004 Feb. PMID 21162294
  3. Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness. Olszewski PK, et al. Am J Physiol Regul Integr Comp Physiol, 2010 Aug. PMID 20427724, Free PMC Article
  4. The role of ERK-1/2 in the N/OFQ-induced inhibition of delayed rectifier potassium currents. Wang W, et al. Biochem Biophys Res Commun, 2010 Apr 16. PMID 20331962
  5. Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats. Ciccocioppo R, et al. Psychopharmacology (Berl), 2004 Mar. PMID 14624331, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
    Title: Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
  2. An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food.
    Title: An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food.
  3. Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers.
    Title: Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.
  4. Nociceptin co-localized only with insulin in pancreatic beta cells.
    Title: Effect of nociceptin on insulin release in normal and diabetic rat pancreas.
  5. LPS-inoculation in rodents is an unsuitable model for studying possible changes in the NOP-N/OFQ system in sepsis.
    Title: Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system.
  6. Results suggest that CaMKII is involved in the inhibitory effect of N/OFQ on delayed rectifier potassium currents in acutely dissociated rat cerebral parietal cortical neurons
    Title: Nociceptin/orphanin FQ-induced inhibition of delayed rectifier potassium currents by calcium/calmodulin-dependent protein kinase type II.
  7. Estradiol negatively modulates the pleiotropic inhibitory actions of nociceptin.
    Title: Estradiol negatively modulates the pleiotropic actions of orphanin FQ/nociceptin at proopiomelanocortin synapses.
  8. These results suggest that N/OFQ can act directly in the nucleus accumbens shell to block cocaine-induced increases in extracellular dopamine levels
    Title: Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity.
  9. The findings suggest a link between N/OFQ and the development of hyperalgesia and allodynia in a rat model of PTSD.
    Title: Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD.
  10. The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
    Title: Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables opioid peptide activity IEA
Inferred from Electronic Annotation
more info
  
enables opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in drinking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in gamma-aminobutyric acid secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron-neuron synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
prepronociceptin
Names
Prepronociceptin (neuropeptide nociceptin) (N23K)
neuropeptide nociceptin 1
nociceptin
orphanin FQ

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013007.1 → NP_037139.1  prepronociceptin precursor

    See identical proteins and their annotated locations for NP_037139.1

    Status: PROVISIONAL

    Source sequence(s)
    X97375
    UniProtKB/Swiss-Prot
    Q62923, Q64162
    UniProtKB/TrEMBL
    A6K6J8
    Related
    ENSRNOP00000019117.6, ENSRNOT00000019117.9
    Conserved Domains (1) summary
    pfam01160
    Location:21 → 66
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    43800240..43827841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093010.2 → XP_038948938.1  prepronociceptin isoform X1

    UniProtKB/TrEMBL
    A6K6J7
    Conserved Domains (1) summary
    pfam01160
    Location:21 → 66
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

  2. XM_006252196.5 → XP_006252258.1  prepronociceptin isoform X1

    See identical proteins and their annotated locations for XP_006252258.1

    UniProtKB/TrEMBL
    A6K6J7
    Conserved Domains (1) summary
    pfam01160
    Location:21 → 66
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

  3. XM_063273998.1 → XP_063130068.1  prepronociceptin isoform X2

    UniProtKB/Swiss-Prot
    Q62923, Q64162
    UniProtKB/TrEMBL
    A6K6J8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62923.1 GenPept UniProtKB/Swiss-Prot:Q62923

Gene LinkOut

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