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TMCO4 transmembrane and coiled-coil domains 4 [ Homo sapiens (human) ]

Gene ID: 255104, updated on 6-Nov-2022

Summary

Official Symbol
TMCO4provided by HGNC
Official Full Name
transmembrane and coiled-coil domains 4provided by HGNC
Primary source
HGNC:HGNC:27393
See related
Ensembl:ENSG00000162542 AllianceGenome:HGNC:27393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 7.2), prostate (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See TMCO4 in Genome Data Viewer
Location:
1p36.13
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (19682240..19799916, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19505616..19623290, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20008733..20126409, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MICOS10-NBL1 readthrough Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene 5-hydroxytryptamine receptor 6 Neighboring gene ring finger protein 186 Neighboring gene uncharacterized LOC105376823 Neighboring gene OTU deubiquitinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686C23231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane and coiled-coil domain-containing protein 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349112.3NP_001336041.1  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031727, AL031730, AL391883
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q9Y3K1
    Conserved Domains (1) summary
    cl21494
    Location:185521
    Abhydrolase; alpha/beta hydrolases
  2. NM_001349113.3NP_001336042.1  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031727, AL031730, AL391883
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q9Y3K1
    Related
    ENSP00000364269.1, ENST00000375127.5
    Conserved Domains (1) summary
    cl21494
    Location:185521
    Abhydrolase; alpha/beta hydrolases
  3. NM_001349114.3NP_001336043.1  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031727, AL031730, AL391883
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q9Y3K1
    Conserved Domains (1) summary
    cl21494
    Location:185521
    Abhydrolase; alpha/beta hydrolases
  4. NM_001349115.1NP_001336044.1  transmembrane and coiled-coil domain-containing protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks multiple 3' coding exons and contains an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK309310, AL031730, AL391883, BX108228
    Conserved Domains (1) summary
    cl21494
    Location:185294
    Abhydrolase; alpha/beta hydrolases
  5. NM_181719.7NP_859070.3  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_859070.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK127543, BM974434, BX640987
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q5TGY1, Q9Y3K1
    Related
    ENSP00000294543.6, ENST00000294543.11
    Conserved Domains (1) summary
    cl21494
    Location:185521
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    19682240..19799916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541185.4XP_011539487.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

    See identical proteins and their annotated locations for XP_011539487.1

    UniProtKB/Swiss-Prot
    Q5TGY1, Q9Y3K1
    Conserved Domains (1) summary
    cl21494
    Location:185521
    Abhydrolase; alpha/beta hydrolases
  2. XM_047416926.1XP_047272882.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  3. XM_011541181.2XP_011539483.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539483.1

    Conserved Domains (1) summary
    pfam05277
    Location:285621
    DUF726; Protein of unknown function (DUF726)
  4. XM_011541179.3XP_011539481.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539481.1

    Conserved Domains (1) summary
    pfam05277
    Location:285621
    DUF726; Protein of unknown function (DUF726)
  5. XM_017000916.2XP_016856405.1  transmembrane and coiled-coil domain-containing protein 4 isoform X2

  6. XM_011541180.3XP_011539482.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539482.1

    Conserved Domains (1) summary
    pfam05277
    Location:285621
    DUF726; Protein of unknown function (DUF726)
  7. XM_047416943.1XP_047272899.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

    UniProtKB/Swiss-Prot
    Q9Y3K1
  8. XM_047416922.1XP_047272878.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  9. XM_047416936.1XP_047272892.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

    UniProtKB/Swiss-Prot
    Q9Y3K1
  10. XM_047416933.1XP_047272889.1  transmembrane and coiled-coil domain-containing protein 4 isoform X3

  11. XM_017000917.2XP_016856406.1  transmembrane and coiled-coil domain-containing protein 4 isoform X4

    Conserved Domains (1) summary
    pfam05277
    Location:244580
    DUF726; Protein of unknown function (DUF726)
  12. XM_047416948.1XP_047272904.1  transmembrane and coiled-coil domain-containing protein 4 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    19505616..19623290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)