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TAC4 tachykinin precursor 4 [ Homo sapiens (human) ]

Gene ID: 255061, updated on 1-Mar-2024

Summary

Official Symbol
TAC4provided by HGNC
Official Full Name
tachykinin precursor 4provided by HGNC
Primary source
HGNC:HGNC:16641
See related
Ensembl:ENSG00000176358 MIM:607833; AllianceGenome:HGNC:16641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EK; HK1; HK-1; PPT-C
Summary
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TAC4 in Genome Data Viewer
Location:
17q21.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49838300..49848069, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50701401..50711169, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47915662..47925431, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47796530-47797090 Neighboring gene family with sequence similarity 117 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47865191-47865964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12372 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47879701-47880202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47880203-47880702 Neighboring gene SRP14 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:47893039-47894031 Neighboring gene lysine acetyltransferase 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:47911219-47911431 Neighboring gene uncharacterized LOC729220 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47938611-47939558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47941593-47942092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47942923-47943617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47948287-47949230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967128-47967965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967966-47968802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47976271-47977012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47980751-47981252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47986569-47987069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47990385-47990940 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:47991434-47992633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47993407-47993919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48001781-48002290 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48005674-48006873 Neighboring gene MPRA-validated peak2887 silencer Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene Neighboring gene RNA, U6 small nuclear 1313, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC133009, MGC133010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables substance P receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of flagellated sperm motility IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in tachykinin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tachykinin-4
Names
endokinin
preprotachykinin-C
tachykinin 4 (hemokinin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029377.2 RefSeqGene

    Range
    5000..14769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077503.2NP_001070971.1  tachykinin-4 isoform beta precursor

    See identical proteins and their annotated locations for NP_001070971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) uses an alternate in-frame splice site in the 5' coding region and skips an alternate in-frame exon in the 3' coding region, compared to variant alpha. The resulting protein (isoform beta) is shorter than isoform alpha.
    Source sequence(s)
    AC027801
    Consensus CDS
    CCDS42359.1
    UniProtKB/Swiss-Prot
    Q86UU9
    Related
    ENSP00000381221.1, ENST00000398154.5
  2. NM_001077504.2NP_001070972.1  tachykinin-4 isoform gamma precursor

    See identical proteins and their annotated locations for NP_001070972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma) uses an alternate in-frame splice site in the 5' coding region and skips an alternate in-frame exon in the 3' coding region, compared to variant alpha. The resulting protein (isoform gamma) is shorter than isoform alpha.
    Source sequence(s)
    AC027801
    Consensus CDS
    CCDS42360.1
    UniProtKB/Swiss-Prot
    Q86UU9
    Related
    ENSP00000325286.5, ENST00000326219.5
  3. NM_001077505.2NP_001070973.1  tachykinin-4 isoform delta precursor

    See identical proteins and their annotated locations for NP_001070973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (delta) uses an alternate in-frame splice site in the 5' coding region and skips two alternate in-frame exons in the 3' coding region, compared to variant alpha. The resulting protein (isoform delta) is shorter than isoform alpha.
    Source sequence(s)
    AC027801
    Consensus CDS
    CCDS42358.1
    UniProtKB/Swiss-Prot
    Q86UU9
    Related
    ENSP00000340461.2, ENST00000352793.6
  4. NM_001077506.2NP_001070974.1  tachykinin-4 isoform alpha-2 precursor

    See identical proteins and their annotated locations for NP_001070974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha-2) uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha. The resulting protein (isoform alpha-2) is shorter than isoform alpha.
    Source sequence(s)
    AC027801
    Consensus CDS
    CCDS45727.1
    UniProtKB/Swiss-Prot
    Q86UU9
    Related
    ENSP00000399702.1, ENST00000436235.6
  5. NM_170685.3NP_733786.2  tachykinin-4 isoform alpha precursor

    See identical proteins and their annotated locations for NP_733786.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AC027801
    Consensus CDS
    CCDS42357.1
    UniProtKB/Swiss-Prot
    Q2M2P1, Q6ECK8, Q86UU6, Q86UU7, Q86UU8, Q86UU9, Q8IWZ7
    Related
    ENSP00000334042.4, ENST00000334568.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    49838300..49848069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    50701401..50711169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)