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TMEM86B transmembrane protein 86B [ Homo sapiens (human) ]

Gene ID: 255043, updated on 2-May-2024

Summary

Official Symbol
TMEM86Bprovided by HGNC
Official Full Name
transmembrane protein 86Bprovided by HGNC
Primary source
HGNC:HGNC:28448
See related
Ensembl:ENSG00000180089 MIM:617806; AllianceGenome:HGNC:28448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables alkenylglycerophosphocholine hydrolase activity; alkenylglycerophosphoethanolamine hydrolase activity; and identical protein binding activity. Involved in ether lipid metabolic process. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in gall bladder (RPKM 7.8), duodenum (RPKM 5.4) and 24 other tissues See more
Orthologs
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Genomic context

Location:
19q13.42
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55226638..55228763, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58320598..58322723, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55738006..55740131, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55701037-55701536 Neighboring gene uncharacterized LOC124904771 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:55729317-55729503 Neighboring gene protein phosphatase 6 regulatory subunit 1 Neighboring gene microRNA 6804 Neighboring gene microRNA 6802

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC30208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-lysine 5,6-aminomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables D-lysine 5,6-aminomutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alkenylglycerophosphocholine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alkenylglycerophosphocholine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ether hydrolase activity TAS
Traceable Author Statement
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ether lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ether lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lysoplasmalogenase TMEM86B
Names
alkenylglycerophosphocholine hydrolase
alkenylglycerophosphoethanolamine hydrolase
lysoplasmalogenase
NP_001358942.1
NP_776165.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372013.1NP_001358942.1  lysoplasmalogenase TMEM86B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010327, BC033193, BX448118, CV029437
    Related
    ENST00000589190.1
    Conserved Domains (1) summary
    pfam07947
    Location:47216
    YhhN; YhhN family
  2. NM_173804.5NP_776165.3  lysoplasmalogenase TMEM86B isoform 1

    See identical proteins and their annotated locations for NP_776165.3

    Status: VALIDATED

    Source sequence(s)
    AC010327, BC023000, BC033193, BX448118, CV029437
    Consensus CDS
    CCDS12920.1
    UniProtKB/Swiss-Prot
    Q8N661
    Related
    ENSP00000321038.3, ENST00000327042.5
    Conserved Domains (1) summary
    pfam07947
    Location:48217
    YhhN; YhhN family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55226638..55228763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58320598..58322723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)