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CALHM1 calcium homeostasis modulator 1 [ Homo sapiens (human) ]

Gene ID: 255022, updated on 12-Aug-2018

Summary

Official Symbol
CALHM1provided by HGNC
Official Full Name
calcium homeostasis modulator 1provided by HGNC
Primary source
HGNC:HGNC:23494
See related
Ensembl:ENSG00000185933 MIM:612234; Vega:OTTHUMG00000018991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM26C
Summary
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CALHM1 in Genome Data Viewer
Location:
10q24.33
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (103453387..103458891, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105213144..105218648, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene programmed cell death 11 Neighboring gene calcium homeostasis modulator family member 2 Neighboring gene NEURL1 antisense RNA 1 Neighboring gene calcium homeostasis modulator 3 Neighboring gene neuralized E3 ubiquitin protein ligase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...

General gene information

Markers

Homology

Clone Names

  • MGC39514, MGC39617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium activated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ATP transport ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cation transport IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
sensory perception of bitter taste ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception of sweet taste ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception of umami taste ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium homeostasis modulator protein 1
Names
family with sequence similarity 26, member C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016855.1 RefSeqGene

    Range
    5001..10505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001412.3NP_001001412.3  calcium homeostasis modulator protein 1

    See identical proteins and their annotated locations for NP_001001412.3

    Status: REVIEWED

    Source sequence(s)
    AL139339
    Consensus CDS
    CCDS7550.1
    UniProtKB/Swiss-Prot
    Q8IU99
    Related
    ENSP00000329926.5, OTTHUMP00000020413, ENST00000329905.5, OTTHUMT00000050165
    Conserved Domains (1) summary
    pfam14798
    Location:5255
    Ca_hom_mod; Calcium homeostasis modulator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    103453387..103458891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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