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Nog noggin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25495, updated on 6-May-2021

Summary

Official Symbol
Nogprovided by RGD
Official Full Name
nogginprovided by RGD
Primary source
RGD:3183
See related
Ensembl:ENSRNOG00000023683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
secreted protein; involved in dorsal fate specification [RGD, Feb 2006]
Orthologs
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Genomic context

See Nog in Genome Data Viewer
Location:
10q26
Exon count:
1
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (74128712..74130339, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76811759..76813386, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene U6atac minor spliceosomal RNA Neighboring gene hypothetical protein LOC688126 Neighboring gene uncharacterized LOC120095173 Neighboring gene uncharacterized LOC102547753 Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC120095174 Neighboring gene transmembrane protein 100 Neighboring gene phosphatidylcholine transfer protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway involved in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in BMP signaling pathway involved in heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial cardiac muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in atrial cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in axial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axial mesoderm development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation in hindbrain IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation in hindbrain ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to BMP stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
involved_in dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic skeletal joint morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic skeletal joint morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in endoderm formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endoderm formation ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within face morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISO
Inferred from Sequence Orthology
more info
 
involved_in forebrain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heart trabecula morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in heart trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in limb development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in membranous septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in membranous septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchymal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
involved_in middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in middle ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neural plate morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural plate morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
 
involved_in notochord morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within notochord morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal arch artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerulus development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glomerulus development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerulus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of oligodendrocyte progenitor proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in prostatic bud formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within prostatic bud formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in somite development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somite development ISO
Inferred from Sequence Orthology
more info
 
involved_in spinal cord development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spinal cord development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
involved_in ureteric bud formation IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within urogenital system development ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular compact myocardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular compact myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012990.1NP_037122.1  noggin precursor

    See identical proteins and their annotated locations for NP_037122.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    UniProtKB/TrEMBL
    G3V8X8
    Related
    ENSRNOP00000030212.3, ENSRNOT00000032388.4
    Conserved Domains (1) summary
    pfam05806
    Location:12232
    Noggin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    74128712..74130339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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