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Nfkbia NFKB inhibitor alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 25493, updated on 17-Nov-2020

Summary

Official Symbol
Nfkbiaprovided by RGD
Official Full Name
NFKB inhibitor alphaprovided by RGD
Primary source
RGD:3171
See related
Ensembl:ENSRNOG00000007390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RL/IF-1
Summary
inhibitor of NF-kappa-B; binds NF kappa B and retains it in the cytoplasm [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 552.7), Spleen (RPKM 414.8) and 9 other tissues See more
Orthologs

Genomic context

See Nfkbia in Genome Data Viewer
Location:
6q23
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (76267227..76270457, complement)
106 current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (71699196..71702411, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (85803990..85807223, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene protein only RNase P catalytic subunit Neighboring gene proteasome 20S subunit alpha 6 Neighboring gene uncharacterized LOC108351237 Neighboring gene uncharacterized LOC102548803 Neighboring gene aldolase 1 A retrogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NF-kappaB binding IC
Inferred by Curator
more info
PubMed 
NF-kappaB binding IPI
Inferred from Physical Interaction
more info
PubMed 
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic sequestering of NF-kappaB IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic sequestering of NF-kappaB ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic sequestering of transcription factor ISO
Inferred from Sequence Orthology
more info
 
leukocyte migration involved in inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
nucleotide-binding oligomerization domain containing 1 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
I-kappaB/NF-kappaB complex IC
Inferred by Curator
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NF-kappa-B inhibitor alpha
Names
I-kappa-B-alpha
Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha
ikB-alpha
ikappaBalpha
nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105720.2NP_001099190.2  NF-kappa-B inhibitor alpha

    See identical proteins and their annotated locations for NP_001099190.2

    Status: VALIDATED

    Source sequence(s)
    BF417507, CA509173, CB316505, CB324027, CB793714
    UniProtKB/Swiss-Prot
    Q63746
    Related
    ENSRNOP00000009894.5, ENSRNOT00000009894.6
    Conserved Domains (4) summary
    cd00204
    Location:105237
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:115212
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:202256
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:143180
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    76267227..76270457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    71699196..71702411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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