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LCE5A late cornified envelope 5A [ Homo sapiens (human) ]

Gene ID: 254910, updated on 5-Jul-2025
Official Symbol
LCE5Aprovided by HGNC
Official Full Name
late cornified envelope 5Aprovided by HGNC
Primary source
HGNC:HGNC:16614
See related
Ensembl:ENSG00000186207 MIM:612619; AllianceGenome:HGNC:16614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEP18; SPRL5A
Summary
Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward skin (RPKM 22.8) See more
Orthologs
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See LCE5A in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152510803..152512177)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151647352..151648726)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152483279..152484653)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 3 pseudogene 1 Neighboring gene cornulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1732 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:152443806-152444710 Neighboring gene cysteine rich C-terminal 1 Neighboring gene late cornified envelope 3E

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Common variants in the trichohyalin gene are associated with straight hair in Europeans.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
late cornified envelope protein 5A
Names
late envelope protein 18
small proline rich-like (epidermal differentiation complex) 5A
small proline-rich-like epidermal differentiation complex protein 5A

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178438.5NP_848525.1  late cornified envelope protein 5A

    See identical proteins and their annotated locations for NP_848525.1

    Status: VALIDATED

    Source sequence(s)
    AL135842
    Consensus CDS
    CCDS1011.1
    UniProtKB/Swiss-Prot
    Q5TCM9
    Related
    ENSP00000333952.2, ENST00000334269.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152510803..152512177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    151647352..151648726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)