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Nes nestin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25491, updated on 22-May-2022

Summary

Symbol
Nesprovided by RGD
Full Name
nestinprovided by RGD
Primary source
RGD:3162
See related
Ensembl:ENSRNOG00000018681 AllianceGenome:RGD:3162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables CCR5 chemokine receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 155.9), Lung (RPKM 113.8) and 8 other tissues See more
Orthologs
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Genomic context

See Nes in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173437867..173447777)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187343109..187352972)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 25B Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene brevican Neighboring gene hyaluronan and proteoglycan link protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables intermediate filament binding IEA
Inferred from Electronic Annotation
more info
 
enables intermediate filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of intermediate filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of intermediate filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308239.1NP_001295168.1  nestin isoform 1

    See identical proteins and their annotated locations for NP_001295168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JACYVU010000069
    UniProtKB/TrEMBL
    G3V8F8
    Related
    ENSRNOP00000025314.2, ENSRNOT00000025314.4
    Conserved Domains (2) summary
    COG5410
    Location:15041610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein
  2. NM_012987.2NP_037119.2  nestin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JACYVU010000069
    Related
    ENSRNOP00000089157.1, ENSRNOT00000100350.1
    Conserved Domains (2) summary
    COG5410
    Location:14161522
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    173437867..173447777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590648.2XP_017446137.1  nestin isoform X1

    UniProtKB/TrEMBL
    G3V8F8
    Conserved Domains (2) summary
    COG5410
    Location:15041610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein