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Nes nestin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25491, updated on 28-Nov-2023

Summary

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Symbol
Nesprovided by RGD
Full Name
nestinprovided by RGD
Primary source
RGD:3162
See related
Ensembl:ENSRNOG00000018681 AllianceGenome:RGD:3162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables CCR5 chemokine receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 155.9), Lung (RPKM 113.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nes in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173437867..173447777)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187343109..187352972)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 25B Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene brevican Neighboring gene hyaluronan and proteoglycan link protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nestin expression and in vivo proliferative potential of tanycytes and ependymal cells lining the walls of the third ventricle in the adult rat brain. Hendrickson ML, et al. Eur J Neurosci, 2018 Feb. PMID 29359828
  2. Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)- cells. Hertig V, et al. PLoS One, 2017. PMID 28448522, Free PMC Article
  3. Endothelial and Epithelial Cell Transition to a Mesenchymal Phenotype Was Delineated by Nestin Expression. Chabot A, et al. J Cell Physiol, 2016 Jul. PMID 26574905
  4. Nestin downregulation in rat vascular smooth muscle cells represents an early marker of vascular disease in experimental type I diabetes. Tardif K, et al. Cardiovasc Diabetol, 2014 Aug 21. PMID 25139503, Free PMC Article
  5. Nestin is a marker of lung remodeling secondary to myocardial infarction and type I diabetes in the rat. Chabot A, et al. J Cell Physiol, 2015 Jan. PMID 24915827

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nestin Regulates Muller Glia Proliferation After Retinal Injury.
    Title: Nestin Regulates Müller Glia Proliferation After Retinal Injury.
  2. Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
    Title: Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
  3. Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
    Title: Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
  4. Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
    Title: Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
  5. Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
    Title: Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
  6. Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
    Title: Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
  7. In the chronic hypoxia/SU5416 animal model of pulmonary hypertension, Nestin+ endothelial cells were found in occlusive pulmonary vascular lesions.
    Title: Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension.
  8. Abundant nestin was present in tanycyte cell bodies and processes and also was observed in patches of ependymal cells as well as in isolated ependymal cells throughout the walls of the 3rdV
    Title: Nestin expression and in vivo proliferative potential of tanycytes and ependymal cells lining the walls of the third ventricle in the adult rat brain.
  9. Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)- cells
    Title: Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)- cells.
  10. In this study, we established stable, nestin promoter-driven tv-a (Ntv-a) transgenic rats. We then introduced the gene transformations previously shown to induce proneural-like brain tumors in mice, and characterized tumor initiation and progression using MRI and MR spectroscopy (MRS).
    Title: Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.
Submit: New GeneRIF Correction See all GeneRIFs (69)

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables intermediate filament binding IEA
Inferred from Electronic Annotation
more info
  
enables intermediate filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of intermediate filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of intermediate filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ionizing radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308239.1 → NP_001295168.1  nestin isoform 1

    See identical proteins and their annotated locations for NP_001295168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JACYVU010000069
    UniProtKB/Swiss-Prot
    P21263, Q8CJ14
    UniProtKB/TrEMBL
    A6J639, G3V8F8
    Related
    ENSRNOP00000025314.2, ENSRNOT00000025314.4
    Conserved Domains (2) summary
    COG5410
    Location:1504 → 1610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7 → 313
    Filament; Intermediate filament protein

  2. NM_012987.2 → NP_037119.2  nestin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JACYVU010000069
    UniProtKB/TrEMBL
    A0A8I6ABC1, A6J640
    Related
    ENSRNOP00000089157.1, ENSRNOT00000100350.1
    Conserved Domains (3) summary
    PTZ00121
    Location:469 → 841
    PTZ00121; MAEBL; Provisional
    pfam17380
    Location:700 → 1026
    DUF5401; Family of unknown function (DUF5401)
    pfam00038
    Location:7 → 313
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    173437867..173447777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590648.2 → XP_017446137.1  nestin isoform X1

    UniProtKB/Swiss-Prot
    P21263, Q8CJ14
    UniProtKB/TrEMBL
    A6J639, G3V8F8
    Conserved Domains (2) summary
    COG5410
    Location:1504 → 1610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7 → 313
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21263.2 GenPept UniProtKB/Swiss-Prot:P21263

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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