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Nes nestin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25491, updated on 21-Jul-2018

Summary

Official Symbol
Nesprovided by RGD
Official Full Name
nestinprovided by RGD
Primary source
RGD:3162
See related
Ensembl:ENSRNOG00000018681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
intermediate filament protein specifically expressed in neuroepithelial stem cells; may play a role in neural cell differentiation [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 155.9), Lung (RPKM 113.8) and 8 other tissues See more
Orthologs

Genomic context

See Nes in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187343109..187352972)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (206746885..206755989)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene ribosomal RNA adenine dimethylase domain containing 1 Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene brevican Neighboring gene hyaluronan and proteoglycan link protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
intermediate filament binding IEA
Inferred from Electronic Annotation
more info
 
intermediate filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of intermediate filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
intermediate filament ISO
Inferred from Sequence Orthology
more info
 
intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308239.1NP_001295168.1  nestin isoform 1

    See identical proteins and their annotated locations for NP_001295168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AABR07072748
    UniProtKB/TrEMBL
    G3V8F8
    Related
    ENSRNOP00000025314.2, ENSRNOT00000025314.3
    Conserved Domains (2) summary
    COG5410
    Location:15041610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein
  2. NM_012987.2NP_037119.2  nestin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AABR07072748
    Conserved Domains (2) summary
    COG5410
    Location:14161522
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    187343109..187352972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590648.1XP_017446137.1  nestin isoform X1

    UniProtKB/TrEMBL
    G3V8F8
    Conserved Domains (2) summary
    COG5410
    Location:15041610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    167386159..167395202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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