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Nes nestin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25491, updated on 15-May-2025
Symbol
Nesprovided by RGD
Full Name
nestinprovided by RGD
Primary source
RGD:3162
See related
Ensembl:ENSRNOG00000018681 AllianceGenome:RGD:3162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables CCR5 chemokine receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in Kidney (RPKM 155.9), Lung (RPKM 113.8) and 8 other tissues See more
Orthologs
human mouse all
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See Nes in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175735715..175745631)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173437867..173447777)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187343109..187352972)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 25B Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene brevican Neighboring gene hyaluronan and proteoglycan link protein 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Human chorionic gonadotropin induces nestin expression in endothelial cells of the ovary via vascular endothelial growth factor signaling. Takahashi N, et al. Endocrinology, 2008 Jan. PMID 17916630
  2. Characterization of nestin expression and vessel association in the ischemic core following focal cerebral ischemia in rats. Shin YJ, et al. Cell Tissue Res, 2013 Mar. PMID 23250576
  3. Evidence for a distinct group of nestin-immunoreactive neurons within the basal forebrain of adult rats. Wang S, et al. Neuroscience, 2006 Nov 3. PMID 16997483
  4. The nestin-expressing and non-expressing neurons in rat basal forebrain display different electrophysiological properties and project to hippocampus. Zhu J, et al. BMC Neurosci, 2011 Dec 20. PMID 22185478, Free PMC Article
  5. Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific. Chamson-Reig A, et al. J Endocrinol, 2006 Oct. PMID 17065391

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging.
    Title: Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging.
  2. Nestin Regulates Muller Glia Proliferation After Retinal Injury.
    Title: Nestin Regulates Müller Glia Proliferation After Retinal Injury.
  3. Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
    Title: Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
  4. Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
    Title: Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells.
  5. Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
    Title: Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
  6. Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
    Title: Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats.
  7. Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
    Title: Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
  8. In the chronic hypoxia/SU5416 animal model of pulmonary hypertension, Nestin+ endothelial cells were found in occlusive pulmonary vascular lesions.
    Title: Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension.
  9. Abundant nestin was present in tanycyte cell bodies and processes and also was observed in patches of ependymal cells as well as in isolated ependymal cells throughout the walls of the 3rdV
    Title: Nestin expression and in vivo proliferative potential of tanycytes and ependymal cells lining the walls of the third ventricle in the adult rat brain.
  10. Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)- cells
    Title: Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)- cells.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables intermediate filament binding IEA
Inferred from Electronic Annotation
more info
  
enables intermediate filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell projection morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of intermediate filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of intermediate filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ionizing radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
nestin

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308239.1 → NP_001295168.1  nestin isoform 1

    See identical proteins and their annotated locations for NP_001295168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P21263, Q8CJ14
    UniProtKB/TrEMBL
    A6J639, G3V8F8
    Related
    ENSRNOP00000025384.7, ENSRNOT00000025384.8
    Conserved Domains (2) summary
    COG5410
    Location:1504 → 1610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7 → 313
    Filament; Intermediate filament protein

  2. NM_012987.2 → NP_037119.2  nestin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ABC1, A6J640
    Related
    ENSRNOP00000089157.2, ENSRNOT00000100350.2
    Conserved Domains (3) summary
    PTZ00121
    Location:469 → 841
    PTZ00121; MAEBL; Provisional
    pfam17380
    Location:700 → 1026
    DUF5401; Family of unknown function (DUF5401)
    pfam00038
    Location:7 → 313
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175735715..175745631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590648.3 → XP_017446137.1  nestin isoform X1

    UniProtKB/Swiss-Prot
    P21263, Q8CJ14
    UniProtKB/TrEMBL
    A6J639, G3V8F8
    Conserved Domains (2) summary
    COG5410
    Location:1504 → 1610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7 → 313
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21263.2 GenPept UniProtKB/Swiss-Prot:P21263

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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