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Nes nestin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25491, updated on 15-May-2025
Symbol
Nesprovided by RGD
Full Name
nestinprovided by RGD
Primary source
RGD:3162
See related
Ensembl:ENSRNOG00000018681 AllianceGenome:RGD:3162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables CCR5 chemokine receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in Kidney (RPKM 155.9), Lung (RPKM 113.8) and 8 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See Nes in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175735715..175745631)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173437867..173447777)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187343109..187352972)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 25B Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene brevican Neighboring gene hyaluronan and proteoglycan link protein 2

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables intermediate filament binding IEA
Inferred from Electronic Annotation
more info
 
enables intermediate filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of intermediate filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of intermediate filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nestin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308239.1NP_001295168.1  nestin isoform 1

    See identical proteins and their annotated locations for NP_001295168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P21263, Q8CJ14
    UniProtKB/TrEMBL
    A6J639, G3V8F8
    Related
    ENSRNOP00000025384.7, ENSRNOT00000025384.8
    Conserved Domains (2) summary
    COG5410
    Location:15041610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein
  2. NM_012987.2NP_037119.2  nestin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ABC1, A6J640
    Related
    ENSRNOP00000089157.2, ENSRNOT00000100350.2
    Conserved Domains (3) summary
    PTZ00121
    Location:469841
    PTZ00121; MAEBL; Provisional
    pfam17380
    Location:7001026
    DUF5401; Family of unknown function (DUF5401)
    pfam00038
    Location:7313
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175735715..175745631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590648.3XP_017446137.1  nestin isoform X1

    UniProtKB/Swiss-Prot
    P21263, Q8CJ14
    UniProtKB/TrEMBL
    A6J639, G3V8F8
    Conserved Domains (2) summary
    COG5410
    Location:15041610
    COG5410; Uncharacterized protein [Function unknown]
    pfam00038
    Location:7313
    Filament; Intermediate filament protein