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Nedd4 NEDD4 E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25489, updated on 5-Sep-2021

Summary

Official Symbol
Nedd4provided by RGD
Official Full Name
NEDD4 E3 ubiquitin protein ligaseprovided by RGD
Primary source
RGD:3157
See related
Ensembl:ENSRNOG00000058898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nedd4a
Summary
may regulate function of the amiloride-sensitive epithelial sodium channel ENaC [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 851.9), Muscle (RPKM 815.1) and 9 other tissues See more
Orthologs
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Genomic context

See Nedd4 in Genome Data Viewer
Location:
8q24
Exon count:
31
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (73384095..73468951)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (79323408..79408842)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene regulatory factor X, 7 Neighboring gene 60S ribosomal protein L21-like Neighboring gene uncharacterized LOC100909416 Neighboring gene similar to mitotic phosphoprotein 44

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphothreonine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding IEA
Inferred from Electronic Annotation
more info
 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
involved_in formation of structure involved in a symbiotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in formation of structure involved in a symbiotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in lysosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in progesterone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein targeting to lysosome IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dendrite morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of potassium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to denervation involved in regulation of muscle adaptation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of viral budding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEDD4
Names
HECT-type E3 ubiquitin transferase NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
neural precursor cell expressed, developmentally down-regulated gene 4
neural precursor cell expressed, developmentally down-regulated gene 4A
NP_037118.1
XP_017450968.1
XP_038936817.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012986.1NP_037118.1  E3 ubiquitin-protein ligase NEDD4

    See identical proteins and their annotated locations for NP_037118.1

    Status: VALIDATED

    Source sequence(s)
    BQ191927, CB326200, CB568921, CB615796, CF110862, CK365888, DY312717, DY318090, EV775947, U50842
    UniProtKB/Swiss-Prot
    Q62940
    UniProtKB/TrEMBL
    A0A0G2K8P3
    Related
    ENSRNOP00000074683.1, ENSRNOT00000088391.1
    Conserved Domains (6) summary
    cd04033
    Location:79210
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:463495
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:556885
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:532886
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:254282
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:407436
    WW; WW domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    73384095..73468951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080889.1XP_038936817.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

    Conserved Domains (5) summary
    cd04033
    Location:79210
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:463495
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:556885
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00201
    Location:254282
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:407436
    WW; WW domain
  2. XM_017595479.2XP_017450968.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

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