Format

Send to:

Choose Destination

ZDHHC23 zinc finger DHHC-type palmitoyltransferase 23 [ Homo sapiens (human) ]

Gene ID: 254887, updated on 13-Mar-2020

Summary

Official Symbol
ZDHHC23provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 23provided by HGNC
Primary source
HGNC:HGNC:28654
See related
Ensembl:ENSG00000184307 MIM:617334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIDD; DHHC-23
Expression
Broad expression in testis (RPKM 5.9), colon (RPKM 3.9) and 24 other tissues See more
Orthologs

Genomic context

See ZDHHC23 in Genome Data Viewer
Location:
3q13.31
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (113947901..113998002)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113666748..113705706)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1C Neighboring gene CTD nuclear envelope phosphatase 1 pseudogene Neighboring gene VPS26A pseudogene 1 Neighboring gene coiled-coil domain containing 191 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene Neighboring gene uncharacterized LOC105374048 Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC42530

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular_component ND
No biological Data available
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC23
Names
zinc finger DHHC domain-containing protein 23
zinc finger DHHC-type containing 23
NP_001307395.1
NP_001307396.1
NP_001307397.1
NP_001350881.1
NP_775841.2
XP_005247326.1
XP_005247327.1
XP_006713625.1
XP_011510920.1
XP_011510921.1
XP_016861573.1
XP_016861575.1
XP_016861576.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320466.2NP_001307395.1  palmitoyltransferase ZDHHC23 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC128687
    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein
  2. NM_001320467.2NP_001307396.1  palmitoyltransferase ZDHHC23 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC128687
    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein
  3. NM_001320468.2NP_001307397.1  palmitoyltransferase ZDHHC23 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC128687
    Conserved Domains (2) summary
    pfam01529
    Location:258381
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein
  4. NM_001363952.1NP_001350881.1  palmitoyltransferase ZDHHC23 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC128687
    Consensus CDS
    CCDS87122.1
    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    cl03934
    Location:96151
    MerC; MerC mercury resistance protein
  5. NM_173570.5NP_775841.2  palmitoyltransferase ZDHHC23 isoform c

    See identical proteins and their annotated locations for NP_775841.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 3' structure, resulting in a distinct 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus, and is shorter, compared to isoform a.
    Source sequence(s)
    AC128687, AF131818, AK127996, BC035230, CA389626
    Consensus CDS
    CCDS33827.1
    UniProtKB/Swiss-Prot
    Q8IYP9
    UniProtKB/TrEMBL
    B3KXV3
    Related
    ENSP00000330485.3, ENST00000330212.7
    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein

RNA

  1. NR_135271.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has a different 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5' most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC128687, AK127025, BC035230, CA389626

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    113947901..113998002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006087.1XP_016861576.1  palmitoyltransferase ZDHHC23 isoform X7

  2. XM_017006084.1XP_016861573.1  palmitoyltransferase ZDHHC23 isoform X2

    Conserved Domains (2) summary
    pfam01529
    Location:258381
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein
  3. XM_011512618.2XP_011510920.1  palmitoyltransferase ZDHHC23 isoform X1

    See identical proteins and their annotated locations for XP_011510920.1

    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein
  4. XM_006713562.3XP_006713625.1  palmitoyltransferase ZDHHC23 isoform X3

    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein
  5. XM_011512619.1XP_011510921.1  palmitoyltransferase ZDHHC23 isoform X4

    UniProtKB/TrEMBL
    E9PAP7
    Related
    ENSP00000420251.1, ENST00000478793.1
    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    cl03934
    Location:96151
    MerC; MerC mercury resistance protein
  6. XM_005247269.1XP_005247326.1  palmitoyltransferase ZDHHC23 isoform X5

    See identical proteins and their annotated locations for XP_005247326.1

    UniProtKB/Swiss-Prot
    Q8IYP9
    Related
    ENSP00000417840.1, ENST00000498275.5
    Conserved Domains (2) summary
    pfam01529
    Location:258384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96151
    MerC; MerC mercury resistance protein
  7. XM_017006086.1XP_016861575.1  palmitoyltransferase ZDHHC23 isoform X6

  8. XM_005247270.3XP_005247327.1  palmitoyltransferase ZDHHC23 isoform X8

    Related
    ENSP00000492287.1, ENST00000638807.1
    Conserved Domains (1) summary
    pfam01529
    Location:97223
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. XR_001740080.1 RNA Sequence

  2. XR_001740079.1 RNA Sequence

  3. XR_924118.3 RNA Sequence

  4. XR_001740081.1 RNA Sequence

  5. XR_924119.1 RNA Sequence

Support Center