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Mmp11 matrix metallopeptidase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25481, updated on 4-Jun-2020

Summary

Official Symbol
Mmp11provided by RGD
Official Full Name
matrix metallopeptidase 11provided by RGD
Primary source
RGD:3099
See related
Ensembl:ENSRNOG00000028344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ST3
Summary
member of the matrix metalloproteinase (MMP) family; may mediate tissue remodeling, highly expressed in healing skin [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 339.0), Kidney (RPKM 64.7) and 5 other tissues See more

Genomic context

See Mmp11 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13670051..13678834)
106 current Rn_Celera (GCF_000002265.2) 20 AC_000088.1 (14222131..14230914)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (15825614..15834397)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene similar to Homo sapiens fetal lung specific expression unknown Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene derlin 3 Neighboring gene macrophage migration inhibitory factor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
basement membrane organization ISO
Inferred from Sequence Orthology
more info
 
collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
stromelysin-3
Names
MMP-11
Matrix metalloproteinase 11 (stromelysin 3)
SL-3
matrix metalloproteinase-11
NP_037112.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012980.2NP_037112.2  stromelysin-3 precursor

    See identical proteins and their annotated locations for NP_037112.2

    Status: VALIDATED

    Source sequence(s)
    BC099781, BI291437, CK602095, U46034
    UniProtKB/Swiss-Prot
    Q499S5
    Related
    ENSRNOP00000035334.4, ENSRNOT00000031400.5
    Conserved Domains (3) summary
    cd00094
    Location:294483
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:108261
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:108261
    Peptidase_M10; Matrixin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    13670051..13678834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    14222131..14230914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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