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Vps35 VPS35 retromer complex component [ Rattus norvegicus (Norway rat) ]

Gene ID: 25479, updated on 9-Jul-2017
Official Symbol
Vps35provided by RGD
Official Full Name
VPS35 retromer complex componentprovided by RGD
Primary source
RGD:1589784
See related
Ensembl:ENSRNOG00000017612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mem3
Summary
mouse homolog is a hydrophilic membrane protein having a direct role in the retrieval of cargo proteins [RGD, Feb 2006]
Orthologs
Location:
19q11
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (27464937..27500636)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (38430733..38466263)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene myosin light chain kinase 3 Neighboring gene origin recognition complex, subunit 6 Neighboring gene mitogen-activated protein kinase 4 pseudogene Neighboring gene olfactory receptor 1666

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
lysosome organization IEA
Inferred from Electronic Annotation
more info
 
lysosome organization ISO
Inferred from Sequence Orthology
more info
 
mitochondrial fragmentation involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mitochondrial fragmentation involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
mitochondrion to lysosome transport IEA
Inferred from Electronic Annotation
more info
 
mitochondrion to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of late endosome to lysosome transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of late endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lysosomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lysosomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter receptor transport, endosome to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor transport, endosome to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt protein secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial fission IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
protein destabilization IEA
Inferred from Electronic Annotation
more info
 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
protein localization to organelle IEA
Inferred from Electronic Annotation
more info
 
protein localization to organelle ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of terminal button organization IEA
Inferred from Electronic Annotation
more info
 
regulation of terminal button organization ISO
Inferred from Sequence Orthology
more info
 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
retrograde transport, endosome to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
transcytosis IEA
Inferred from Electronic Annotation
more info
 
transcytosis ISO
Inferred from Sequence Orthology
more info
 
voluntary musculoskeletal movement IEA
Inferred from Electronic Annotation
more info
 
voluntary musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
mitochondrion-derived vesicle IEA
Inferred from Electronic Annotation
more info
 
mitochondrion-derived vesicle ISO
Inferred from Sequence Orthology
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density of dendrite IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density of dendrite ISO
Inferred from Sequence Orthology
more info
 
retromer complex IDA
Inferred from Direct Assay
more info
PubMed 
retromer complex ISO
Inferred from Sequence Orthology
more info
 
retromer, cargo-selective complex IEA
Inferred from Electronic Annotation
more info
 
retromer, cargo-selective complex ISO
Inferred from Sequence Orthology
more info
 
tubular endosome IEA
Inferred from Electronic Annotation
more info
 
tubular endosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
vacuolar protein sorting-associated protein 35
Names
Maternal embryonic message 3
vacuolar protein sorting 35 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105718.2NP_001099188.2  vacuolar protein sorting-associated protein 35

    See identical proteins and their annotated locations for NP_001099188.2

    Status: VALIDATED

    Source sequence(s)
    AABR07043339, BP475974, CB583538, CB732662, CK596387, CV106736, CV120410, DV725274, EV778075
    UniProtKB/TrEMBL
    G3V8A5
    Related
    ENSRNOP00000024020.4, ENSRNOT00000024020.5
    Conserved Domains (1) summary
    pfam03635
    Location:15752
    Vps35; Vacuolar protein sorting-associated protein 35

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    27464937..27500636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    21625446..21661413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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