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OR6C3 olfactory receptor family 6 subfamily C member 3 [ Homo sapiens (human) ]

Gene ID: 254786, updated on 5-Jan-2022

Summary

Official Symbol
OR6C3provided by HGNC
Official Full Name
olfactory receptor family 6 subfamily C member 3provided by HGNC
Primary source
HGNC:HGNC:15437
See related
Ensembl:ENSG00000205329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OST709
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
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Genomic context

See OR6C3 in Genome Data Viewer
Location:
12q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (55330043..55332636)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (55725485..55726420)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily C member 5 pseudogene Neighboring gene olfactory receptor family 6 subfamily C member 1 Neighboring gene olfactory receptor family 6 subfamily C member 7 pseudogene Neighboring gene olfactory receptor family 6 subfamily C member 75

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
GeneReviews: Not available

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 6C3
Names
HSA8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388498.1NP_001375427.1  olfactory receptor 6C3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122684
    Related
    ENSP00000493380.1, ENST00000641740.2
    Conserved Domains (1) summary
    cd15912
    Location:22291
    7tmA_OR6C-like; olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_054104.2NP_473445.1  olfactory receptor 6C3 isoform 1

    See identical proteins and their annotated locations for NP_473445.1

    Status: VALIDATED

    Source sequence(s)
    AC122684
    Consensus CDS
    CCDS31819.1
    UniProtKB/Swiss-Prot
    Q9NZP0
    UniProtKB/TrEMBL
    A0A126GW44
    Related
    ENSP00000493034.1, ENST00000641364.1
    Conserved Domains (1) summary
    cd15912
    Location:22291
    7tmA_OR6C-like; olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    55330043..55332636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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