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LYG2 lysozyme g2 [ Homo sapiens (human) ]

Gene ID: 254773, updated on 5-Aug-2022

Summary

Official Symbol
LYG2provided by HGNC
Official Full Name
lysozyme g2provided by HGNC
Primary source
HGNC:HGNC:29615
See related
Ensembl:ENSG00000185674 MIM:616547; AllianceGenome:HGNC:29615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYGH; LYGA2; LYSG2
Summary
The protein encoded by this gene contains a SLT domain, a protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See LYG2 in Genome Data Viewer
Location:
2q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (99242246..99261522, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99701128..99714289, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99858709..99872129, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene lipoyltransferase 1 Neighboring gene microtubule interacting and trafficking domain containing 1 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene uncharacterized LOC107985923 Neighboring gene lysozyme g1 Neighboring gene thioredoxin domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119046, MGC119047, MGC119049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysozyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lysozyme g-like protein 2
Names
lysozyme G-like 2
NP_783862.2
XP_016859240.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175735.4NP_783862.2  lysozyme g-like protein 2 precursor

    See identical proteins and their annotated locations for NP_783862.2

    Status: REVIEWED

    Source sequence(s)
    AC079447
    Consensus CDS
    CCDS2042.1
    UniProtKB/Swiss-Prot
    Q53RW0, Q86SG7
    Related
    ENSP00000327533.2, ENST00000333017.7
    Conserved Domains (1) summary
    cd01021
    Location:53210
    GEWL; Goose Egg White Lysozyme domain. Eukaryotic "goose-type" lysozymes (GEWL). These enzymes catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Members include tunicate, Japanese ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    99242246..99261522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003751.3XP_016859240.1  lysozyme g-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53RW0, Q86SG7
    Conserved Domains (1) summary
    cd01021
    Location:53210
    GEWL; Goose Egg White Lysozyme domain. Eukaryotic "goose-type" lysozymes (GEWL). These enzymes catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Members include tunicate, Japanese ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    99701128..99714289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)