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Kcna4 potassium voltage-gated channel subfamily A member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25469, updated on 8-Dec-2022

Summary

Official Symbol
Kcna4provided by RGD
Official Full Name
potassium voltage-gated channel subfamily A member 4provided by RGD
Primary source
RGD:2952
See related
Ensembl:ENSRNOG00000004918 AllianceGenome:RGD:2952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kv4; RK3; RHK1; KCHAN; Kv1.4
Summary
Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in several cellular components, including asymmetric synapse; cell surface; and dendrite. Is integral component of plasma membrane. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Orthologous to human KCNA4 (potassium voltage-gated channel subfamily A member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 102.7), Heart (RPKM 70.8) and 1 other tissue See more
Orthologs
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Genomic context

See Kcna4 in Genome Data Viewer
Location:
3q33
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (93756399..93778004)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (98293295..98300763)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor like GTPase 14 effector protein Neighboring gene follicle stimulating hormone subunit beta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon initial segment IEA
Inferred from Electronic Annotation
more info
 
is_active_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 4
Names
RCK4
potassium channel, voltage gated shaker related subfamily A, member 4
potassium voltage-gated channel, shaker-related subfamily, member 4
voltage-gated potassium channel subunit Kv1.4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012971.3NP_037103.2  potassium voltage-gated channel subfamily A member 4

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000118
    UniProtKB/TrEMBL
    G3V6L7
    Conserved Domains (3) summary
    cl38908
    Location:177304
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:307571
    Ion_trans; Ion transport protein
    pfam07941
    Location:137
    K_channel_TID; Potassium channel Kv1.4 tandem inactivation domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    93756399..93778004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234673.4XP_006234735.1  potassium voltage-gated channel subfamily A member 4 isoform X1

    See identical proteins and their annotated locations for XP_006234735.1

    UniProtKB/TrEMBL
    G3V6L7
    Related
    ENSRNOP00000006524.4, ENSRNOT00000006524.6
    Conserved Domains (3) summary
    cl38908
    Location:177304
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:307571
    Ion_trans; Ion transport protein
    pfam07941
    Location:137
    K_channel_TID; Potassium channel Kv1.4 tandem inactivation domain
  2. XM_006234674.4XP_006234736.1  potassium voltage-gated channel subfamily A member 4 isoform X1

    See identical proteins and their annotated locations for XP_006234736.1

    UniProtKB/TrEMBL
    G3V6L7
    Conserved Domains (3) summary
    cl38908
    Location:177304
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:307571
    Ion_trans; Ion transport protein
    pfam07941
    Location:137
    K_channel_TID; Potassium channel Kv1.4 tandem inactivation domain