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Irs1 insulin receptor substrate 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25467, updated on 19-Aug-2018

Summary

Official Symbol
Irs1provided by RGD
Official Full Name
insulin receptor substrate 1provided by RGD
Primary source
RGD:2922
See related
Ensembl:ENSRNOG00000014597
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IRS1IRM
Summary
a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 289.3), Heart (RPKM 135.2) and 9 other tissues See more
Orthologs

Genomic context

See Irs1 in Genome Data Viewer
Location:
9q34
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (88033668..88086488, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (87782499..87835248, complement)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553709 Neighboring gene uncharacterized LOC108351961 Neighboring gene proline-rich protein 2-like Neighboring gene uncharacterized LOC108351962 Neighboring gene rhomboid domain containing 1 Neighboring gene collagen type IV alpha 4 chain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol 3-kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to angiotensin IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to brain-derived neurotrophic factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
NOT insulin secretion ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of somatostatin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucagon secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import in response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucose import in response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
response to caffeine IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
caveola IEA
Inferred from Electronic Annotation
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
insulin receptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin receptor substrate 1
Names
IRS-1
pp185

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012969.1NP_037101.1  insulin receptor substrate 1

    See identical proteins and their annotated locations for NP_037101.1

    Status: PROVISIONAL

    Source sequence(s)
    X58375
    UniProtKB/Swiss-Prot
    P35570
    Related
    ENSRNOP00000019579.4, ENSRNOT00000019579.5
    Conserved Domains (3) summary
    cd01204
    Location:155258
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:17110
    PH; PH domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    88033668..88086488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    80997490..81050250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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