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Icam1 intercellular adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25464, updated on 30-Sep-2021

Summary

Symbol
Icam1provided by RGD
Full Name
intercellular adhesion molecule 1provided by RGD
Primary source
RGD:2857
See related
EnsemblRapid:ENSRNOG00000020679
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD54; ICAM
Summary
cell adhesion molecule; ligand for leukocyte adhesion molecule LFA-1 [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 685.4), Spleen (RPKM 148.9) and 5 other tissues See more
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Genomic context

See Icam1 in Genome Data Viewer
Location:
8q13
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19553063..19565438)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22035287..22047049)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene intercellular adhesion molecule 4, Landsteiner-Wiener blood group Neighboring gene intercellular adhesion molecule 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adhesion of symbiont to host ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to alkaloid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interferon-gamma IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in establishment of Sertoli cell barrier IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration TAS
Traceable Author Statement
more info
PubMed 
involved_in membrane to membrane docking ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to gonadotropin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to sulfur dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
intercellular adhesion molecule 1
Names
ICAM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012967.1NP_037099.1  intercellular adhesion molecule 1 precursor

    See identical proteins and their annotated locations for NP_037099.1

    Status: PROVISIONAL

    Source sequence(s)
    D00913
    UniProtKB/Swiss-Prot
    Q00238
    Related
    ENSRNOP00000028066.3, ENSRNOT00000028066.6
    Conserved Domains (5) summary
    cd05755
    Location:113204
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    cd07689
    Location:311399
    Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00410
    Location:416486
    IG_like; Immunoglobulin like
    pfam03921
    Location:24110
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:423488
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    19553063..19565438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080880.1XP_038936808.1  intercellular adhesion molecule 1 isoform X1

    Conserved Domains (4) summary
    smart00409
    Location:406476
    IG; Immunoglobulin
    pfam13895
    Location:312382
    Ig_2; Immunoglobulin domain
    cd05755
    Location:112207
    IgC2_2_ICAM-1_like; Second immunoglobulin (Ig)-like C2-set domain of intercellular cell adhesion molecule 1 (ICAM-1), and similar domains
    cd20996
    Location:28110
    IgI_N_ICAM-1; N-terminal immunoglobulin domain of the intercellular adhesion molecules ICAM-1 (Cluster of Differentiation 54 or CD54); member of the I-set of IgSF domains
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