U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NUDT8 nudix hydrolase 8 [ Homo sapiens (human) ]

Gene ID: 254552, updated on 19-Sep-2024

Summary

Official Symbol
NUDT8provided by HGNC
Official Full Name
nudix hydrolase 8provided by HGNC
Primary source
HGNC:HGNC:8055
See related
Ensembl:ENSG00000167799 AllianceGenome:HGNC:8055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable magnesium ion binding activity and manganese ion binding activity. Predicted to be involved in purine nucleoside bisphosphate catabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 5.4), heart (RPKM 4.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NUDT8 in Genome Data Viewer
Location:
11q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67627938..67629937, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67622625..67624624, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67395409..67397408, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67381921-67382434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67382435-67382950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67382951-67383466 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67383983-67384496 Neighboring gene double C2 domain gamma, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:67384509-67385123 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67386492-67387365 Neighboring gene uncharacterized LOC124902696 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:67388663-67389245 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:67389246-67389827 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67393084-67393613 Neighboring gene Sharpr-MPRA regulatory region 370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67399437-67399966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67400495-67401024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67401025-67401552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67401848-67402406 Neighboring gene T-box transcription factor 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67402407-67402965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67411697-67412266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67412267-67412834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5119 Neighboring gene aminoacylase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67416073-67416595

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ41567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coenzyme A diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in butyryl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in coenzyme A catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in malonyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in medium-chain fatty-acyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in propionyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in succinyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitochondrial coenzyme A diphosphatase NUDT8
Names
nucleoside diphosphate-linked moiety X motif 8, mitochondrial
nudix (nucleoside diphosphate linked moiety X)-type motif 8
nudix motif 8
NP_001230679.1
NP_862826.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243750.2NP_001230679.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform 1

    See identical proteins and their annotated locations for NP_001230679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK123561, AP003385, CB140633
    Consensus CDS
    CCDS58151.1
    UniProtKB/Swiss-Prot
    Q6ZW59, Q8WV74
    Related
    ENSP00000365883.2, ENST00000376693.3
    Conserved Domains (1) summary
    cd03426
    Location:32186
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  2. NM_181843.3NP_862826.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform 2

    See identical proteins and their annotated locations for NP_862826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP003385, BC018644, CB140633
    Consensus CDS
    CCDS8174.1
    UniProtKB/Swiss-Prot
    Q8WV74
    Related
    ENSP00000301490.4, ENST00000301490.8
    Conserved Domains (1) summary
    cd03426
    Location:32137
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    67627938..67629937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    67622625..67624624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)