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NUDT8 nudix hydrolase 8 [ Homo sapiens (human) ]

Gene ID: 254552, updated on 25-Jan-2022

Summary

Official Symbol
NUDT8provided by HGNC
Official Full Name
nudix hydrolase 8provided by HGNC
Primary source
HGNC:HGNC:8055
See related
Ensembl:ENSG00000167799 AllianceGenome:HGNC:8055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable magnesium ion binding activity and manganese ion binding activity. Predicted to be involved in purine nucleoside bisphosphate catabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in kidney (RPKM 5.4), heart (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See NUDT8 in Genome Data Viewer
Location:
11q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67621421..67629937, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67395409..67397408, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene double C2 domain gamma, pseudogene Neighboring gene T-box transcription factor 10 Neighboring gene aminoacylase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CoA pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in butyryl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in coenzyme A catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in malonyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in medium-chain fatty-acyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in propionyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in succinyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitochondrial coenzyme A diphosphatase NUDT8; nucleoside diphosphate-linked moiety X motif 8
Names
nucleoside diphosphate-linked moiety X motif 8, mitochondrial
nudix (nucleoside diphosphate linked moiety X)-type motif 8
nudix motif 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243750.2NP_001230679.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform 1

    See identical proteins and their annotated locations for NP_001230679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK123561, AP003385, CB140633
    Consensus CDS
    CCDS58151.1
    UniProtKB/Swiss-Prot
    Q8WV74
    Related
    ENSP00000365883.2, ENST00000376693.3
    Conserved Domains (1) summary
    cd03426
    Location:32186
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  2. NM_181843.3NP_862826.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform 2

    See identical proteins and their annotated locations for NP_862826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP003385, BC018644, CB140633
    Consensus CDS
    CCDS8174.1
    UniProtKB/Swiss-Prot
    Q8WV74
    Related
    ENSP00000301490.4, ENST00000301490.8
    Conserved Domains (1) summary
    cd03426
    Location:32137
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67621421..67629937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017474.2XP_016872963.1  nucleoside diphosphate-linked moiety X motif 8 isoform X1

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