Format

Send to:

Choose Destination

LPCAT4 lysophosphatidylcholine acyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 254531, updated on 13-Mar-2020

Summary

Official Symbol
LPCAT4provided by HGNC
Official Full Name
lysophosphatidylcholine acyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:30059
See related
Ensembl:ENSG00000176454 MIM:612039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AYTL3; AGPAT7; LPEAT2; LPAAT-eta
Summary
Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Expression
Ubiquitous expression in stomach (RPKM 27.5), duodenum (RPKM 20.5) and 23 other tissues See more
Orthologs

Genomic context

See LPCAT4 in Genome Data Viewer
Location:
15q14
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (34358633..34367196, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34651089..34659397, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NOP10 ribonucleoprotein Neighboring gene NUT midline carcinoma family member 1 Neighboring gene actin gamma 1 pseudogene 15 Neighboring gene golgin A8 family member A Neighboring gene microRNA 1233-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10257

Gene Ontology Provided by GOA

Process Evidence Code Pubs
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
lysophospholipid acyltransferase LPCAT4
Names
1-AGP acyltransferase 7
1-AGPAT 7
1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
1-acylglycerophosphocholine O-acyltransferase
1-acylglycerophosphoserine O-acyltransferase
1-alkenylglycerophosphoethanolamine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
PLSC domain containing protein
acyl-CoA:lysophosphatidylethanolamine acyltransferase 2
acyltransferase-like 3
lysophosphatidylethanolamine acyltransferase 2
plasmalogen synthase
NP_705841.2
XP_006720517.1
XP_011519724.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153613.3NP_705841.2  lysophospholipid acyltransferase LPCAT4

    See identical proteins and their annotated locations for NP_705841.2

    Status: VALIDATED

    Source sequence(s)
    AC025678, BC048430, BC092463, T29943
    Consensus CDS
    CCDS32191.1
    UniProtKB/Swiss-Prot
    Q643R3
    Related
    ENSP00000317300.6, ENST00000314891.11
    Conserved Domains (1) summary
    cd07991
    Location:109306
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    34358633..34367196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521422.1XP_011519724.1  lysophospholipid acyltransferase LPCAT4 isoform X2

    Related
    ENSP00000478003.1, ENST00000617710.4
    Conserved Domains (1) summary
    cl17185
    Location:50138
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
  2. XM_006720454.2XP_006720517.1  lysophospholipid acyltransferase LPCAT4 isoform X1

    Conserved Domains (2) summary
    cd07991
    Location:109306
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:109237
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RNA

  1. XR_243088.1 RNA Sequence

  2. XR_243087.1 RNA Sequence

  3. XR_002957632.1 RNA Sequence

  4. XR_931784.1 RNA Sequence

Support Center