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Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25451, updated on 12-Jan-2022

Summary

Official Symbol
Gabrb2provided by RGD
Official Full Name
gamma-aminobutyric acid type A receptor subunit beta 2provided by RGD
Primary source
RGD:2650
See related
Ensembl:ENSRNOG00000003680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GARB2
Summary
Enables GABA-A receptor activity; chloride channel activity; and inhibitory extracellular ligand-gated ion channel activity. Contributes to GABA receptor activity. Involved in GABAergic synaptic transmission; cellular response to histamine; and chloride transmembrane transport. Located in cytosol and membrane. Is integral component of plasma membrane. Part of GABA-A receptor complex. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward (RPKM 272.9) See more
Orthologs
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Genomic context

See Gabrb2 in Genome Data Viewer
Location:
10q21
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (26936592..27156141)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (27973694..28193072)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352216 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha6 Neighboring gene ATPase phospholipid transporting 10B (putative) Neighboring gene probable phospholipid-transporting ATPase VD Neighboring gene uncharacterized LOC120095072 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to histamine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in inhibitory synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in inhibitory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inner ear receptor cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in innervation ISO
Inferred from Sequence Orthology
more info
 
involved_in ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic transmission, GABAergic IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of GABA receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of GABA-A receptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of GABA-A receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in integral component of postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
gamma-aminobutyric acid receptor subunit beta-2
Names
GABA(A) receptor subunit beta-2
Gamma-aminobutyric acid receptor beta 2
gamma-aminobutyric acid (GABA) A receptor, beta 2
gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
gamma-aminobutyric acid type A receptor beta 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012957.2NP_037089.1  gamma-aminobutyric acid receptor subunit beta-2 precursor

    See identical proteins and their annotated locations for NP_037089.1

    Status: PROVISIONAL

    Source sequence(s)
    AY574251
    UniProtKB/Swiss-Prot
    P63138
    Related
    ENSRNOP00000091812.1, ENSRNOT00000118954.1
    Conserved Domains (1) summary
    TIGR00860
    Location:9472
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    26936592..27156141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767635.3XP_008765857.1  gamma-aminobutyric acid receptor subunit beta-2 isoform X2

    Related
    ENSRNOP00000004970.4, ENSRNOT00000004970.6
    Conserved Domains (3) summary
    TIGR00860
    Location:9504
    LIC; Cation transporter family protein
    pfam02931
    Location:40242
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:249501
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  2. XM_006246127.3XP_006246189.1  gamma-aminobutyric acid receptor subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006246189.1

    UniProtKB/Swiss-Prot
    P63138
    Related
    ENSRNOP00000081083.1, ENSRNOT00000118632.1
    Conserved Domains (1) summary
    TIGR00860
    Location:9472
    LIC; Cation transporter family protein
  3. XM_039085275.1XP_038941203.1  gamma-aminobutyric acid receptor subunit beta-2 isoform X1

    Conserved Domains (1) summary
    TIGR00860
    Location:9472
    LIC; Cation transporter family protein
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