Fcer1g Fc epsilon receptor Ig [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcer1gprovided by RGD
Official Full Name: Fc epsilon receptor Igprovided by RGD
Primary source: RGD:2599
See related: Ensembl:ENSRNOG00000024159 AllianceGenome:RGD:2599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor signaling pathway; and defense response to other organism. Predicted to act upstream of or within several processes, including negative regulation of mast cell apoptotic process; positive regulation of cytokine production; and positive regulation of immune effector process. Part of Fc-gamma receptor III complex. Orthologous to human FCER1G (Fc epsilon receptor Ig). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Spleen (RPKM 482.7), Lung (RPKM 308.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86181908..86186766, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83649447..83654248, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89601894..89606326, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mast cells contribute to Mincle-mediated immunity through Syk activation triggered by association with the FcepsilonRIbetagamma complex.
Title: Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.
This study showed that CCL2, NF-kappaB1, RAC2, FCER1G and C1Q may contribute to the generation of neuropathic pain after sciatic nerve injury via immune and defense pathways.
Title: Gene expression profile changes in rat dorsal horn after sciatic nerve injury.
The results presented in this paper suggest that the Mincle/MCL/FcepsilonRI-gamma complex is the functionally optimal form for these C-type lectin receptors on the surface of myeloid cells.
Title: Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ.
substitution of FcR-gamma T22 with non-polar amino acids does not interfere with surface expression of the FcvarepsilonRI and its signaling capacity
Title: Fc receptor-γ subunits with both polar or non-polar amino acids at position of T22 are capable of restoring surface expression of the high-affinity IgE receptor and degranulation in γ subunit-deficient rat basophilic leukemia cells.
Phospholipase D1 activity by regulating phosphatidic acid formation controls the early signals initiated by FcepsilonRI aggregation that lead to mast cell degranulation.
Title: Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation.
Among the proteins that bind to phosphorylated beta ITAM of the FcepsilonRI-beta are Syk, Grb2, Shc, SHIP, and SHP-1, and binding does not depend on previous cell activation.
Title: Analysis of proteins binding to the ITAM motif of the beta-subunit of the high-affinity receptor for IgE (FcepsilonRI).

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgE binding	IEA Inferred from Electronic Annotation more info
contributes_to IgE binding	ISO Inferred from Sequence Orthology more info
enables IgE binding	ISO Inferred from Sequence Orthology more info
enables IgE receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables IgE receptor activity	IEA Inferred from Electronic Annotation more info
enables IgE receptor activity	ISO Inferred from Sequence Orthology more info
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Fc receptor mediated stimulatory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Fc-epsilon receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Fc-gamma receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Fc-gamma receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell differentiation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-3-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mast cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mast cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type III hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of platelet activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in serotonin secretion by platelet	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Fc-epsilon receptor I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Fc-epsilon receptor I complex	IEA Inferred from Electronic Annotation more info
part_of Fc-epsilon receptor I complex	ISO Inferred from Sequence Orthology more info
part_of Fc-gamma receptor III complex	IDA Inferred from Direct Assay more info	PubMed
part_of Fc-gamma receptor III complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high affinity immunoglobulin epsilon receptor subunit gamma

Names: Fc fragment of IgE receptor Ig; Fc fragment of IgE, high affinity I, receptor for; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; Fc receptor gamma-chain; Fc receptor, IgE, high affinity I, gamma polypeptide; fc-epsilon RI-gamma; fcRgamma; fceRI gamma; gamma polypeptide; igE Fc receptor subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131001.2 → NP_001124473.1 high affinity immunoglobulin epsilon receptor subunit gamma precursor

See identical proteins and their annotated locations for NP_001124473.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the protein-coding variant.

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P20411

UniProtKB/TrEMBL

A0A8I6AI77, B1H251

Related

ENSRNOP00000102941.1, ENSRNOT00000140295.1

Conserved Domains (2) summary

smart00077
Location:62 → 82

ITAM; Immunoreceptor tyrosine-based activation motif

pfam11628
Location:21 → 51

TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RNA

NR_175264.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

Related

ENSRNOT00000103998.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

86181908..86186766 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090390.2 → XP_038946318.1 high affinity immunoglobulin epsilon receptor subunit gamma isoform X3

UniProtKB/TrEMBL

A0A8I6AI77, A0A8I6GIE3

Conserved Domains (2) summary

smart00077
Location:54 → 74

ITAM; Immunoreceptor tyrosine-based activation motif

pfam11628
Location:13 → 43

TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain
XM_063272045.1 → XP_063128115.1 high affinity immunoglobulin epsilon receptor subunit gamma isoform X1
XM_063272047.1 → XP_063128117.1 high affinity immunoglobulin epsilon receptor subunit gamma isoform X2