mag1 DNA-3-methyladenine glycosylase Mag1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Gene symbol: mag1
Gene description: DNA-3-methyladenine glycosylase Mag1
Primary source: PomBase:SPAPB24D3.04c
Locus tag: SPAPB24D3.04c
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The crystal structure of Schizosaccharomyces pombe Mag1 (spMag1) in complex with DNA, is reported.
Title: Analysis of substrate specificity of Schizosaccharomyces pombe Mag1 alkylpurine DNA glycosylase.
The substrate specificity of Mag1 is confined to alkylated bases.
Title: Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-1,N6-ethenoadenine N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-3-methyladenine glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-3-methyladenine glycosylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-7-methylguanine glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-7-methylguanine glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-7-methylguanine glycosylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables alkylated DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables alkylated DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables alkylbase DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA dealkylation involved in DNA repair	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in DNA dealkylation involved in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair, AP site formation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in base-excision repair, AP site formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-DNA complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed

NP_593991.1

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