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dsc4 DSC E3 ubiquitin ligase complex subunit Dsc4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543396, updated on 18-Sep-2024
Official Symbol
dsc4
Official Full Name
DSC E3 ubiquitin ligase complex subunit Dsc4
Primary source
PomBase:SPAC4D7.11
Locus tag
SPOM_SPAC4D7.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5372034..5373807)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene translation initiation factor eIF2B gamma subunit tif223 Neighboring gene ncRNA Neighboring gene SAGA complex subunit Spt20 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein new13 Neighboring gene ncRNA Neighboring gene GTPase Fet5 Neighboring gene U1 snRNP-associated protein Prp40

Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors. Burr R, et al. J Biol Chem, 2017 Mar 31. PMID 28202541, Free PMC Article
  2. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. Raychaudhuri S, et al. J Biol Chem, 2015 Jun 5. PMID 25918164, Free PMC Article
  3. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Chong R, et al. J Biol Chem, 2013 Jul 12. PMID 23729666, Free PMC Article
  4. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. Stewart EV, et al. J Biol Chem, 2012 Jan 2. PMID 22086920, Free PMC Article
  5. Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Lloyd SJ, et al. J Biol Chem, 2013 Jul 19. PMID 23760507, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in SREBP signaling pathway EXP
Inferred from Experiment
more info
 PubMed 
involved_in SREBP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Dsc E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Dsc E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Dsc E3 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in endoplasmic reticulum HDA PubMed 
Preferred Names
DSC E3 ubiquitin ligase complex subunit Dsc4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5372034..5373807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020395.3 → NP_594964.1  DSC E3 ubiquitin ligase complex subunit Dsc4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594964.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14175
    Conserved Domains (1) summary
    pfam08508
    Location:18 → 129
    DUF1746; Fungal domain of unknown function (DUF1746)
Nucleotide Protein
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