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msh3 DNA mismatch repair protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543392, updated on 13-Mar-2024

Summary

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Gene symbol
msh3
Gene description
DNA mismatch repair protein
Locus tag
SPAC8F11.03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
swi4
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Genomic context

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Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (2855630..2859170)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene putative HSR1-like GTP-binding protein Neighboring gene putative ribosome biogenesis protein Ltv1 Neighboring gene 60S ribosomal protein L41 Neighboring gene putative diphthamide biosynthesis protein Dph3 Neighboring gene miscRNA Neighboring gene putative U3 snoRNP-associated Cic1/Utp30 family protein Neighboring gene protein mug130 Neighboring gene nuclear envelope protein Brr6/Brl1 Neighboring gene DNA replication protein Cdc24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The swi4+ gene of Schizosaccharomyces pombe encodes a homologue of mismatch repair enzymes. Fleck O, et al. Nucleic Acids Res, 1992 May 11. PMID 1317550, Free PMC Article
  2. Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats. Villahermosa D, et al. G3 (Bethesda), 2017 May 5. PMID 28341698, Free PMC Article
  3. Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe. Tornier C, et al. Genetics, 2001 May. PMID 11333218, Free PMC Article
  4. Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Mansour AA, et al. Genetics, 2001 May. PMID 11333219, Free PMC Article
  5. Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination. Su J, et al. PLoS Genet, 2021 Jul. PMID 34292936, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stability of hepta-nucleotide repeats requires Msh3 and Exo1 in MMR-independent processes.
    Title: Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to Y-form DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-strand/single-strand DNA junction binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to heteroduplex DNA loop binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair NAS
Non-traceable Author Statement
more info
  
involved_in gene conversion at mating-type locus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in mismatch repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2855630..2859170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019379.2 → NP_593952.1  DNA mismatch repair protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593952.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P26359
    Conserved Domains (6) summary
    cd03287
    Location:733 → 954
    ABC_MSH3_euk; ATP-binding cassette domain of eukaryotic MutS3 homolog
    COG0249
    Location:98 → 1002
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:104 → 217
    MutS_I; MutS domain I
    pfam05188
    Location:233 → 386
    MutS_II; MutS domain II
    pfam05190
    Location:589 → 675
    MutS_IV; MutS family domain IV
    pfam05192
    Location:407 → 554
    MutS_III; MutS domain III
Nucleotide Protein
Heading Accession and Version

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