U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mre11 Mre11 nuclease [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542757, updated on 15-Apr-2026
Official Symbol
mre11
Official Full Name
Mre11 nuclease
Primary source
PomBase:SPAC13C5.07
Locus tag
SPOM_SPAC13C5.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rad32
Try the new Gene page
Try the new Transcripts and proteins table
See mre11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (436179..439980)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein mug121 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks. Audry J, et al. Nucleic Acids Res, 2024 Apr 24. PMID 38321948, Free PMC Article
  2. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Williams RS, et al. Cell, 2008 Oct 3. PMID 18854158, Free PMC Article
  3. Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe. Ellermeier C, et al. Proc Natl Acad Sci U S A, 2005 Aug 2. PMID 16043696, Free PMC Article
  4. Functional interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex. Bonfils S, et al. J Cell Sci, 2011 Apr 15. PMID 21429938, Free PMC Article
  5. Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance. Ueno M, et al. Mol Cell Biol, 2003 Sep. PMID 12944481, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.
    Title: Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.
  2. A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
    Title: A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
  3. a mre11 mutant defective in endonucleolytic activity, the same mutant lacking Ctp1, or the triple mutant also lacking the putative hairpin nuclease Pso2 showed wild-type levels of repair. Thus, MRN (Mre11-Rad50-Nbs1)may act to recruit the hairpin opening activity that allows subsequent repair
    Title: Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe.
  4. Mre11-Rad50-Nbs1 participates in checkpoint-dependent replication slowing through negative regulation of recombination.
    Title: The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.
  5. Rad32 nuclease has the catalytic site for Rec12-oligonucleotide generation and is activated by Ctp1, which plays an additional role in meiotic recombination.
    Title: Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
  6. Study finds that in the presence of the MRN (Rad32-Rad50-Nbs1) complex efficient recombination requires Ctp1, the ortholog of the nuclease Sae2, but not the nuclease activity of MRN.
    Title: Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination.
  7. The Mre11-Rad50-Nbs1 S-phase checkpoint role is separate from its Ctp1- and resection-dependent role in double-strand break repair.
    Title: The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling.
  8. This study demonstrates for the first time that Mre11 (Schizosaccharomyces pombe Rad32(Mre11)) nuclease activity is required for the removal of Rec12(Spo11).
    Title: Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions.
  9. Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well as Top1 from 3' ends in vivo and a ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal.
    Title: Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
  10. The conserved Mre11/Rad50/Nbs1 (MRN) complex is likely directly involved in processing palindromes through the homologous recombination pathway of DNA repair. [Mre11]
    Title: A novel recombination pathway initiated by the Mre11/Rad50/Nbs1 complex eliminates palindromes during meiosis in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA end binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables Y-form DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables double-stranded DNA 3'-5' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in double-strand break repair involved in meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mre11 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Mre11 complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Mre11 nuclease

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    436179..439980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018336.3 → NP_592935.1  Mre11 nuclease [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592935.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09683
    Conserved Domains (3) summary
    TIGR00583
    Location:15 → 414
    mre11; DNA repair protein (mre11)
    cd00840
    Location:19 → 280
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    pfam04152
    Location:301 → 467
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.