Format

Send to:

Choose Destination

Cyp51 cytochrome P450, family 51 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25427, updated on 27-Nov-2020

Summary

Official Symbol
Cyp51provided by RGD
Official Full Name
cytochrome P450, family 51provided by RGD
Primary source
RGD:2481
See related
Ensembl:ENSRNOG00000007234
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp51a1; RATCP14DM
Summary
gene amplification is detected in some endometrial carcinomas [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 913.2), Brain (RPKM 436.4) and 9 other tissues See more
Orthologs

Genomic context

See Cyp51 in Genome Data Viewer
Location:
4q13
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27175564..27194018)
106 current Rn_Celera (GCF_000002265.2) 4 AC_000072.1 (25462810..25481264)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (27078790..27097244)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene disks large homolog 5-like Neighboring gene uncharacterized LOC108350665 Neighboring gene A-kinase anchoring protein 9 Neighboring gene uncharacterized LOC108350666 Neighboring gene mitochondrial transcription termination factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93630

Gene Ontology Provided by RGD

Function Evidence Code Pubs
heme binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol 14-demethylase activity IDA
Inferred from Direct Assay
more info
PubMed 
sterol 14-demethylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cholesterol biosynthetic process via 24,25-dihydrolanosterol IDA
Inferred from Direct Assay
more info
PubMed 
demethylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cholesterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lanosterol 14-alpha demethylase
Names
CYPLI
Cytochrom P450 Lanosterol 14 alpha-demethylase
LDM
P450-14DM
P45014DM
P450LI
cytochrome P450 51A1
cytochrome P450 Lanosterol 14 alpha-demethylase
cytochrome P450, subfamily 51
cytochrome P450-14DM
cytochrome P45014DM
cytochrome P450LI
sterol 14-alpha demethylase
NP_037073.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012941.3NP_037073.1  lanosterol 14-alpha demethylase

    See identical proteins and their annotated locations for NP_037073.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000141
    UniProtKB/Swiss-Prot
    Q64654
    Related
    ENSRNOP00000009985.3, ENSRNOT00000009985.5
    Conserved Domains (1) summary
    cl12078
    Location:67477
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    27175564..27194018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    25462810..25481264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center