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dcp2 mRNA-decapping complex catalytic subunit Dcp2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542503, updated on 15-Apr-2026
Official Symbol
dcp2
Official Full Name
mRNA-decapping complex catalytic subunit Dcp2
Primary source
PomBase:SPAC19A8.12
Locus tag
SPOM_SPAC19A8.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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See dcp2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2462202..2465047, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene aminoacyl-tRNA hydrolase Neighboring gene U1 snRNP-associated protein Usp101 Neighboring gene recombination protein Irc6 Neighboring gene SUMO-targeted ubiquitin-protein ligase subunit Rfp1 Neighboring gene ncRNA Neighboring gene transport protein Yos1

Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Control of mRNA decapping by autoinhibition. Paquette DR, et al. Nucleic Acids Res, 2018 Jul 6. PMID 29618050, Free PMC Article
  2. A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping. Schütz S, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28472520, Free PMC Article
  3. Structural basis of dcp2 recognition and activation by dcp1. She M, et al. Mol Cell, 2008 Feb 15. PMID 18280239, Free PMC Article
  4. Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. Floor SN, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323607, Free PMC Article
  5. Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme. Wurm JP, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533364, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation.
    Title: Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation.
  2. Elements in the C-terminus of Dcp2 inhibit decapping at the catalytic step.
    Title: Control of mRNA decapping by autoinhibition.
  3. Authors demonstrate that only three of the six domain orientations are present in solution, where Dcp2 adopts an open, a closed, or a catalytically active state, and show how mRNA substrate and the activator proteins Dcp1 and Edc1 influence the dynamic equilibria between these states and how this modulates catalytic activity.
    Title: Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme.
  4. These results determine the dynamics of the open-to-closed transition in Dcp2.
    Title: Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.
  5. This study reports a 1.6-A-resolution crystal structure of the Schizosaccharomyces pombe Dcp2-Dcp1 heterodimer in an unprecedented conformation that is tied together by an intrinsically disordered peptide from Edc1.
    Title: Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
  6. Here is presented a 2.6-A-resolution crystal structure of a heterotrimer of fission yeast Dcp2, its essential activator Dcp1 and the human NMD cofactor PNRC2, in complex with a tight-binding cap analog.
    Title: Structural basis of mRNA-cap recognition by Dcp1-Dcp2.
  7. Edc3 & Scd6 stimulate decapping in vitro, presumably by preventing the Dcp1:Dcp2 complex from adopting an inactive conformation. Protein interactions via LSm & HLM domains were identified.
    Title: The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
  8. mRNA decapping is promoted by an RNA-binding channel in dcp2.
    Title: mRNA decapping is promoted by an RNA-binding channel in Dcp2.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity EXP
Inferred from Experiment
more info
 PubMed 
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA cap binding EXP
Inferred from Experiment
more info
 PubMed 
enables magnesium ion binding TAS
Traceable Author Statement
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA methylguanosine-cap decapping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
part_of RNA decapping complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
Preferred Names
mRNA-decapping complex catalytic subunit Dcp2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2462202..2465047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019209.3 → NP_593780.1  mRNA-decapping complex catalytic subunit Dcp2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593780.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13828
    Conserved Domains (2) summary
    cd03672
    Location:96 → 240
    Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
    pfam05026
    Location:11 → 93
    DCP2; Dcp2, box A domain
Nucleotide Protein
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