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cpy1 vacuolar carboxypeptidase Y [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542465, updated on 15-Mar-2024

Summary

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Gene symbol
cpy1
Gene description
vacuolar carboxypeptidase Y
Primary source
PomBase:SPAC19G12.10c
Locus tag
SPAC19G12.10c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
pcy1
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4061377..4064952, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene NADH/NADPH-dependent indole-3-acetaldehyde reductase AKR3C2 Neighboring gene protein erh1 Neighboring gene putative ubiquinone biosynthesis protein Coq9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vacuolar protein sorting in fission yeast: cloning, biosynthesis, transport, and processing of carboxypeptidase Y from Schizosaccharomyces pombe. Tabuchi M, et al. J Bacteriol, 1997 Jul. PMID 9209031, Free PMC Article
  2. Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe. Mukaiyama H, et al. Appl Microbiol Biotechnol, 2011 Apr. PMID 21153812
  3. S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p. Codlin S, et al. J Cell Sci, 2009 Apr 15. PMID 19299465, Free PMC Article
  4. The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein. Taricani L, et al. J Biol Chem, 2002 Mar 22. PMID 11751918
  5. Predicting the fission yeast protein interaction network. Pancaldi V, et al. G3 (Bethesda), 2012 Apr. PMID 22540037, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Isp6p and Psp3p are functional in the vacuole and are involved in proteolytic processing of carboxypeptidase Y and alkaline phosphatase.
    Title: Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe.
  2. S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.
    Title: S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process in the vacuole ISO
Inferred from Sequence Orthology
more info
  
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in fungal-type vacuole HDA PubMed 
is_active_in fungal-type vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vacuolar carboxypeptidase Y
NP_594425.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4061377..4064952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019854.2 → NP_594425.1  vacuolar carboxypeptidase Y [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594425.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13849, O14366
    Conserved Domains (3) summary
    COG2939
    Location:540 → 998
    Kex1; Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]
    pfam00450
    Location:578 → 998
    Peptidase_S10; Serine carboxypeptidase
    pfam16009
    Location:344 → 419
    DUF4779; Domain of unknown function (DUF4779)
Nucleotide Protein
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