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BPIFC BPI fold containing family C [ Homo sapiens (human) ]

Gene ID: 254240, updated on 11-Jun-2021

Summary

Official Symbol
BPIFCprovided by HGNC
Official Full Name
BPI fold containing family Cprovided by HGNC
Primary source
HGNC:HGNC:16503
See related
Ensembl:ENSG00000184459 MIM:614109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPIL2
Expression
Restricted expression toward skin (RPKM 18.4) See more
Orthologs
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Genomic context

See BPIFC in Genome Data Viewer
Location:
22q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (32413845..32464465, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (32809834..32853373, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator like 4 pseudogene Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase Neighboring gene F-box protein 7 Neighboring gene synapsin III Neighboring gene SYN3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipopolysaccharide binding NAS
Non-traceable Author Statement
more info
PubMed 
enables phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
BPI fold-containing family C protein
Names
BPI-like 2
bactericidal/permeability-increasing protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174932.3NP_777592.1  BPI fold-containing family C protein precursor

    See identical proteins and their annotated locations for NP_777592.1

    Status: VALIDATED

    Source sequence(s)
    AF465766, AL021937, CK823453, CU456409
    Consensus CDS
    CCDS13906.1
    UniProtKB/Swiss-Prot
    Q8NFQ6
    Related
    ENSP00000300399.3, ENST00000300399.8
    Conserved Domains (2) summary
    pfam01273
    Location:38210
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
    cl00188
    Location:242478
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    32413845..32464465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530091.2XP_011528393.1  BPI fold-containing family C protein isoform X2

    Conserved Domains (1) summary
    cl00188
    Location:190426
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
  2. XM_017028740.1XP_016884229.1  BPI fold-containing family C protein isoform X3

  3. XM_011530090.2XP_011528392.1  BPI fold-containing family C protein isoform X1

    See identical proteins and their annotated locations for XP_011528392.1

    UniProtKB/Swiss-Prot
    Q8NFQ6
    Conserved Domains (2) summary
    pfam01273
    Location:38210
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
    cl00188
    Location:242478
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
  4. XM_011530089.2XP_011528391.1  BPI fold-containing family C protein isoform X1

    See identical proteins and their annotated locations for XP_011528391.1

    UniProtKB/Swiss-Prot
    Q8NFQ6
    Conserved Domains (2) summary
    pfam01273
    Location:38210
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
    cl00188
    Location:242478
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
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