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Ctsc cathepsin C [ Rattus norvegicus (Norway rat) ]

Gene ID: 25423, updated on 30-Sep-2021

Summary

Official Symbol
Ctscprovided by RGD
Official Full Name
cathepsin Cprovided by RGD
Primary source
RGD:2445
See related
EnsemblRapid:ENSRNOG00000016496
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CATC; DPPI; DPP-I
Summary
acts as a cysteine dipeptidyl aminopeptidase; may play a role in immune and inflammatory response [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 604.8), Kidney (RPKM 269.7) and 7 other tissues See more
Orthologs
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Genomic context

See Ctsc in Genome Data Viewer
Location:
1q32
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (142028386..142059841)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (151918514..151949979)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 5 Neighboring gene eukaryotic translation initiation factor 5-like Neighboring gene uncharacterized LOC102554680 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAB38, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chloride ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables dipeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dipeptidyl peptidase 1
Names
cathepsin J
dipeptidyl peptidase I
dipeptidyl transferase
NP_058793.1
XP_008757859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017097.2NP_058793.1  dipeptidyl peptidase 1 precursor

    See identical proteins and their annotated locations for NP_058793.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000041
    UniProtKB/Swiss-Prot
    P80067
    Related
    ENSRNOP00000022342.3, ENSRNOT00000022342.6
    Conserved Domains (3) summary
    cd02621
    Location:230459
    Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
    cl28439
    Location:168204
    Pox_I6; Poxvirus I6-like family
    pfam08773
    Location:25138
    CathepsinC_exc; Cathepsin C exclusion domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    142028386..142059841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759637.3XP_008757859.1  dipeptidyl peptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_008757859.1

    Related
    ENSRNOP00000085136.1, ENSRNOT00000097085.1
    Conserved Domains (1) summary
    pfam08773
    Location:26106
    CathepsinC_exc; Cathepsin C exclusion domain
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