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its3 1-phosphatidylinositol-4-phosphate 5-kinase Its3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542231, updated on 19-Nov-2025
Official Symbol
its3
Official Full Name
1-phosphatidylinositol-4-phosphate 5-kinase Its3
Primary source
PomBase:SPAC19G12.14
Locus tag
SPOM_SPAC19G12.14
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mss4
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See its3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (4072136..4075036)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene decaprenyl diphosphate synthase subunit 2 Dlp1 Neighboring gene protein Poz1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene trehalose-6-phosphate phosphatase Tpp1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Fission yeast Opy1 is an endogenous PI(4,5)P(2) sensor that binds to the phosphatidylinositol 4-phosphate 5-kinase Its3. Snider CE, et al. J Cell Sci, 2020 Dec 3. PMID 33172987, Free PMC Article
  2. Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast. Zhang Y, et al. J Biol Chem, 2000 Nov 10. PMID 10950958
  3. Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I. Vancurova I, et al. J Biol Chem, 1999 Jan 8. PMID 9873063
  4. Fission yeast myosin I facilitates PI(4,5)P(2)-mediated anchoring of cytoplasmic dynein to the cortex. Thankachan JM, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28292899, Free PMC Article
  5. Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling. Li C, et al. Genes Cells, 2014 Mar. PMID 24350606

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a mechanism whereby PI4P5K signaling/localization is affected by Golgi membrane trafficking, proviing a functional link between the PI4,5P2 signaling and Rab-mediated trafficking.
    Title: Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling.
  2. Its3 PIP5K regulates cell integrity through a Plc1-mediated PKC-independent pathway, in addition to the Rho/PKC pathway
    Title: Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 4-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in dynein-driven meiotic oscillatory nuclear movement EXP
Inferred from Experiment
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
1-phosphatidylinositol-4-phosphate 5-kinase Its3

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4072136..4075036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019858.3 → NP_594429.1  1-phosphatidylinositol-4-phosphate 5-kinase Its3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594429.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13853
    Conserved Domains (2) summary
    smart00330
    Location:294 → 662
    PIPKc; Phosphatidylinositol phosphate kinases
    COG5253
    Location:1 → 667
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version

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