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mkh1 MEK kinase (MEKK) Mkh1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542175, updated on 14-Jul-2022

Summary

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Gene symbol
mkh1
Gene description
MEK kinase (MEKK) Mkh1
Primary source
PomBase:SPAC1F3.02c
Locus tag
SPAC1F3.02c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See mkh1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (613369..617324, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene sec14 cytosolic factor family Sec14 Neighboring gene putative exosome 3'-5' exoribonuclease subunit Rrp6 Neighboring gene putative Lgl family protein Neighboring gene putative SSU-rRNA maturation protein Tsr3 Neighboring gene adaptin family protein Neighboring gene sporulation protein Spo15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe. Loewith R, et al. J Cell Sci, 2000 Jan. PMID 10591634
  2. Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe. Madrid M, et al. J Biol Chem, 2006 Jan 27. PMID 16291757
  3. The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway. Merla A, et al. Curr Genet, 2001 Jun. PMID 11453249
  4. MAP kinase kinase kinase (MAPKKK)-dependent and -independent activation of Sty1 stress MAPK in fission yeast. Zhou X, et al. J Biol Chem, 2010 Oct 22. PMID 20729203, Free PMC Article
  5. The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch. Sugiura R, et al. Nature, 1999 Jun 3. PMID 10365961

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables MAP kinase kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall integrity MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization or biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MEK kinase (MEKK) Mkh1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    613369..617324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018404.2 → NP_593005.1  MEK kinase (MEKK) Mkh1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593005.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10407
    Conserved Domains (2) summary
    smart00220
    Location:825 → 1094
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06629
    Location:823 → 1094
    STKc_Bck1_like; Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases
Nucleotide Protein
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