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mei2 RNA-binding protein Mei2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542080, updated on 18-Sep-2024

Summary

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Official Symbol
mei2
Official Full Name
RNA-binding protein Mei2
Primary source
PomBase:SPAC27D7.03c
Locus tag
SPOM_SPAC27D7.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4510983..4515025, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GRIP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context. Jeffares DC, et al. Dev Genes Evol, 2004 Mar. PMID 14986133
  2. The fission yeast meiotic regulator Mei2p forms a dot structure in the horse-tail nucleus in association with the sme2 locus on chromosome II. Shimada T, et al. Mol Biol Cell, 2003 Jun. PMID 12808043, Free PMC Article
  3. Structural insights reveal the specific recognition of meiRNA by the Mei2 protein. Shen S, et al. J Mol Cell Biol, 2022 Sep 19. PMID 35512546, Free PMC Article
  4. A scaffold lncRNA shapes the mitosis to meiosis switch. Andric V, et al. Nat Commun, 2021 Feb 3. PMID 33536434, Free PMC Article
  5. meiRNA, A Polyvalent Player in Fission Yeast Meiosis. Yamashita A. Noncoding RNA, 2019 Sep 17. PMID 31533287, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study suggests that at meiotic initiation, Mei2 may sequester rep2 mRNA to help allow pre-meiotic S, and then may bind both meiRNA and mmi1 mRNA to inactivate Mmi1 at two levels, the protein level and also the mRNA level, allowing meiosis.
    Title: mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe.
  2. The authors propose that Mmi1 recruits the Ccr4-Not complex to counteract its own inhibitor Mei2, thereby locking the system in a stable state that ensures the repression of the meiotic program by Mmi1.
    Title: Ubiquitination-dependent control of sexual differentiation in fission yeast.
  3. Mei2 is polyubiquitylated in vivo in a TORC1-dependent manner.
    Title: S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase.
  4. Mei2 tethers Mmi1 and thereby stabilizes the transcripts necessary for the progression of meiosis
    Title: The selective elimination of messenger RNA underlies the mitosis-meiosis switch in fission yeast.
  5. While the C-terminal RNA recognition motif is highly conserved between plants and fungi, indicating conservation of molecular mechanisms, plant Mei2-like genes have changed biological context to regulate various aspects of developmental pattern formation.
    Title: A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables poly(U) RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle switching, mitotic to meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of conjugation with zygote IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of metaphase/anaphase transition of meiosis II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Mei2 nuclear dot complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Mei2 nuclear dot complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Tor2-Mei2-Ste11 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding protein Mei2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4510983..4515025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020037.3 → NP_594609.1  RNA-binding protein Mei2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594609.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08965
    Conserved Domains (3) summary
    cd12275
    Location:194 → 265
    RRM1_MEI2_EAR1_like; RNA recognition motif 1 in Mei2-like proteins and terminal EAR1-like proteins
    cd12528
    Location:287 → 362
    RRM2_MEI2_fungi; RNA recognition motif 2 in fungal Mei2-like proteins
    cl17169
    Location:596 → 692
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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