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ufd2 ubiquitin-protein ligase E4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542023, updated on 15-Apr-2026
Official Symbol
ufd2
Official Full Name
ubiquitin-protein ligase E4
Primary source
PomBase:SPAC20H4.10
Locus tag
SPOM_SPAC20H4.10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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See ufd2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (2128441..2131713)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphatase activator Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rho family GTPase Rho5 Neighboring gene ncRNA Neighboring gene family protein ICE2 Neighboring gene 40S ribosomal protein uS12

Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast. Gatti L, et al. BMC Genomics, 2011 Jan 19. PMID 21247416, Free PMC Article
  2. Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase. Jang YJ, et al. Yeast, 2013 Oct. PMID 23640764
  3. The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain. Hänzelmann P, et al. J Biol Chem, 2010 Jun 25. PMID 20427284, Free PMC Article
  4. Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe. Xu X, et al. G3 (Bethesda), 2018 Mar 2. PMID 29352077, Free PMC Article
  5. A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast. Paul SK, et al. FEBS J, 2009 Sep. PMID 19682301

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ufd2 induces cell death in prolonged nutrient deprivation, that Sds23/Psp1/Moc1 may be a target protein of the ubiquitin-fusion degradation pathway for regulation of cell viability under this stress condition.
    Title: Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.
  2. Data show that ufd2 mutants exhibiting resistance to cisplatin.
    Title: Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ubiquitin-protein ligase E4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2128441..2131713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019061.3 → NP_593630.1  ubiquitin-protein ligase E4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593630.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60009, Q9HE05, Q9P7A3, Q9UTT4, Q9UU63
    Conserved Domains (3) summary
    COG5113
    Location:76 → 1010
    UFD2; Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]
    pfam04564
    Location:931 → 1003
    U-box; U-box domain
    pfam10408
    Location:290 → 914
    Ufd2P_core; Ubiquitin elongating factor core
Nucleotide Protein
Heading Accession and Version

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