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Cryab crystallin, alpha B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25420, updated on 27-Nov-2024

Summary

Official Symbol
Cryabprovided by RGD
Official Full Name
crystallin, alpha Bprovided by RGD
Primary source
RGD:2414
See related
EnsemblRapid:ENSRNOG00000010524 AllianceGenome:RGD:2414
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AACRYA
Summary
This gene encodes subunit b, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. Alternate promoter usage results in different transcript variants encoding the same protein. [provided by RefSeq, Sep 2014]
Expression
Biased expression in Heart (RPKM 17469.9), Muscle (RPKM 7981.4) and 2 other tissues See more
Orthologs
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Genomic context

See Cryab in Genome Data Viewer
Location:
8q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59989885..59995532)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51093441..51099161)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55178543..55182546)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DIX domain containing 1 Neighboring gene uncharacterized LOC120094337 Neighboring gene similar to human chromosome 11 open reading frame 52 Neighboring gene heat shock protein family B (small) member 2 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene 2 Neighboring gene cilia and flagella associated protein 68

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of eye lens TAS
Traceable Author Statement
more info
PubMed 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle organ development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intracellular transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tubulin complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in I band IDA
Inferred from Direct Assay
more info
PubMed 
located_in M band IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament bundle IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cardiac myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in contractile muscle fiber ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-crystallin B chain
Names
Crystallin, alpha polypeptide 2
alpha(B)-crystallin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012935.4NP_037067.1  alpha-crystallin B chain

    See identical proteins and their annotated locations for NP_037067.1

    Status: REVIEWED

    Source sequence(s)
    CK357656, M55534
    UniProtKB/Swiss-Prot
    P23928, Q6LDR2
    UniProtKB/TrEMBL
    A6J4F4
    Conserved Domains (2) summary
    cd06498
    Location:67150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:152
    Crystallin; Alpha crystallin A chain, N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    59989885..59995532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080879.2XP_038936807.1  alpha-crystallin B chain isoform X1

    UniProtKB/Swiss-Prot
    P23928, Q6LDR2
    UniProtKB/TrEMBL
    A6J4F4
    Related
    ENSRNOP00000055901.2, ENSRNOT00000059127.5
    Conserved Domains (2) summary
    cd06498
    Location:67150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:152
    Crystallin; Alpha crystallin A chain, N terminal
  2. XM_039080878.2XP_038936806.1  alpha-crystallin B chain isoform X1

    UniProtKB/Swiss-Prot
    P23928, Q6LDR2
    UniProtKB/TrEMBL
    A6J4F4
    Conserved Domains (2) summary
    cd06498
    Location:67150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:152
    Crystallin; Alpha crystallin A chain, N terminal