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SLC37A4 solute carrier family 37 member 4 [ Homo sapiens (human) ]

Gene ID: 2542, updated on 1-Mar-2024

Summary

Official Symbol
SLC37A4provided by HGNC
Official Full Name
solute carrier family 37 member 4provided by HGNC
Primary source
HGNC:HGNC:4061
See related
Ensembl:ENSG00000137700 MIM:602671; AllianceGenome:HGNC:4061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G6PT; SPX4; CDG2W; G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
Summary
This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
Annotation information
Annotation category: suggests misassembly
Expression
Broad expression in kidney (RPKM 40.6), duodenum (RPKM 31.3) and 24 other tissues See more
Orthologs
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Genomic context

See SLC37A4 in Genome Data Viewer
Location:
11q23.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (119024112..119030877, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (119044474..119051238, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118894822..118901587, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene centrosomal AT-AC splicing factor Neighboring gene ribosomal protein L23a pseudogene 64 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5616 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118889349-118890047 Neighboring gene ribosomal protein S25 Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3962 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:118906707-118906861 Neighboring gene HYOU1 antisense RNA 1 Neighboring gene hypoxia up-regulated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5617 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118927013-118927514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118927515-118928014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5618 Neighboring gene uncharacterized LOC124902769

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC15729

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis TAS
Traceable Author Statement
more info
 
involved_in glucose metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose-6-phosphate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose-6-phosphate transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphate ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
glucose-6-phosphate exchanger SLC37A4
Names
glucose-5-phosphate transporter
glucose-6-phosphatase transporter
glucose-6-phosphatase, transport (glucose) protein 3
glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2
glucose-6-phosphate translocase
microsomal glucose-6-phosphate transporter
solute carrier family 37 (glucose-6-phosphate transporter), member 4
sugar-phosphate exchange protein 4
transformation-related gene 19 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013331.1 RefSeqGene

    Range
    5001..11555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_187

mRNA and Protein(s)

  1. NM_001164277.2NP_001157749.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

    See identical proteins and their annotated locations for NP_001157749.1

    Status: REVIEWED

    Source sequence(s)
    AP003392, FP885832
    UniProtKB/Swiss-Prot
    O43826, O96016, Q5J7V4, Q9UI19, Q9UNS4
    UniProtKB/TrEMBL
    A8K0S7, Q6IBR9, U3KPU7, U3KQV0
    Related
    ENST00000525102.5
    Conserved Domains (1) summary
    TIGR00881
    Location:18397
    2A0104; phosphoglycerate transporter family protein
  2. NM_001164278.2NP_001157750.1  glucose-6-phosphate exchanger SLC37A4 isoform 2

    See identical proteins and their annotated locations for NP_001157750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AP003392, FP885832
    UniProtKB/TrEMBL
    U3KQS2
    Related
    ENSP00000476176.2, ENST00000357590.9
    Conserved Domains (2) summary
    cd06174
    Location:14437
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00881
    Location:18419
    2A0104; phosphoglycerate transporter family protein
  3. NM_001164279.2NP_001157751.1  glucose-6-phosphate exchanger SLC37A4 isoform 3

    See identical proteins and their annotated locations for NP_001157751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AP003392, FP885832
    UniProtKB/TrEMBL
    B4DUH2, U3KQL4
    Related
    ENSP00000475991.2, ENST00000538950.5
    Conserved Domains (1) summary
    cd06174
    Location:4342
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  4. NM_001164280.2NP_001157752.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

    See identical proteins and their annotated locations for NP_001157752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AP003392, FP885832
    UniProtKB/Swiss-Prot
    O43826, O96016, Q5J7V4, Q9UI19, Q9UNS4
    UniProtKB/TrEMBL
    A8K0S7, Q6IBR9, U3KPU7, U3KQV0
    Conserved Domains (1) summary
    TIGR00881
    Location:18397
    2A0104; phosphoglycerate transporter family protein
  5. NM_001467.6NP_001458.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

    See identical proteins and their annotated locations for NP_001458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AP003392, FP885832
    UniProtKB/Swiss-Prot
    O43826, O96016, Q5J7V4, Q9UI19, Q9UNS4
    UniProtKB/TrEMBL
    A8K0S7, Q6IBR9, U3KPU7, U3KQV0
    Related
    ENST00000527992.5
    Conserved Domains (1) summary
    TIGR00881
    Location:18397
    2A0104; phosphoglycerate transporter family protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    119024112..119030877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646203.1 Reference GRCh38.p14 PATCHES

    Range
    45712..52476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    119044474..119051238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)