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SLC37A4 solute carrier family 37 member 4 [ Homo sapiens (human) ]

Gene ID: 2542, updated on 1-Jun-2020

Summary

Official Symbol
SLC37A4provided by HGNC
Official Full Name
solute carrier family 37 member 4provided by HGNC
Primary source
HGNC:HGNC:4061
See related
Ensembl:ENSG00000137700 MIM:602671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
Summary
This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
Expression
Broad expression in kidney (RPKM 40.6), duodenum (RPKM 31.3) and 24 other tissues See more
Orthologs

Genomic context

See SLC37A4 in Genome Data Viewer
Location:
11q23.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119024112..119030906, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118895061..118901616, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 84 Neighboring gene ribosomal protein L23a pseudogene 64 Neighboring gene ribosomal protein S25 Neighboring gene trafficking protein particle complex 4 Neighboring gene hypoxia up-regulated 1 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15729

Gene Ontology Provided by GOA

Process Evidence Code Pubs
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
glucose metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
PubMed 
glucose-6-phosphate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose-6-phosphate transport NAS
Non-traceable Author Statement
more info
PubMed 
phosphate ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
glucose-6-phosphate exchanger SLC37A4
Names
glucose-5-phosphate transporter
glucose-6-phosphatase, transport (glucose) protein 3
glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2
glucose-6-phosphate translocase
microsomal glucose-6-phosphate transporter
solute carrier family 37 (glucose-6-phosphate transporter), member 4
transformation-related gene 19 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013331.1 RefSeqGene

    Range
    5001..11555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_187

mRNA and Protein(s)

  1. NM_001164277.1NP_001157749.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

    See identical proteins and their annotated locations for NP_001157749.1

    Status: REVIEWED

    Source sequence(s)
    AK289642, AP003392, BC015650, BM506735, DC295438
    UniProtKB/Swiss-Prot
    O43826
    UniProtKB/TrEMBL
    A0A024R3H9, A8K0S7
    Related
    ENST00000525102.5
    Conserved Domains (1) summary
    TIGR00881
    Location:18397
    2A0104; phosphoglycerate transporter family protein
  2. NM_001164278.2NP_001157750.1  glucose-6-phosphate exchanger SLC37A4 isoform 2

    See identical proteins and their annotated locations for NP_001157750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK312628, AP003392, BC014663, BC064563, BI091679
    UniProtKB/Swiss-Prot
    O43826
    UniProtKB/TrEMBL
    A0A024R3L1
    Related
    ENSP00000476176.2, ENST00000357590.9
    Conserved Domains (2) summary
    cd06174
    Location:14437
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00881
    Location:18419
    2A0104; phosphoglycerate transporter family protein
  3. NM_001164279.2NP_001157751.1  glucose-6-phosphate exchanger SLC37A4 isoform 3

    See identical proteins and their annotated locations for NP_001157751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK300646, AP003392, BC064563, BI091679, DC295438
    UniProtKB/Swiss-Prot
    O43826
    UniProtKB/TrEMBL
    B4DUH2
    Related
    ENSP00000475991.2, ENST00000538950.5
    Conserved Domains (1) summary
    cd06174
    Location:4342
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  4. NM_001164280.2NP_001157752.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

    See identical proteins and their annotated locations for NP_001157752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AP003392, BC002400, BC064563, BI091679
    UniProtKB/Swiss-Prot
    O43826
    UniProtKB/TrEMBL
    A0A024R3H9
    Conserved Domains (1) summary
    TIGR00881
    Location:18397
    2A0104; phosphoglycerate transporter family protein
  5. NM_001467.6NP_001458.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

    See identical proteins and their annotated locations for NP_001458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AP003392, BC014663, BI091679, DC295438
    UniProtKB/Swiss-Prot
    O43826
    UniProtKB/TrEMBL
    A0A024R3H9
    Related
    ENST00000527992.5
    Conserved Domains (1) summary
    TIGR00881
    Location:18397
    2A0104; phosphoglycerate transporter family protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    119024112..119030906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646203.1 Reference GRCh38.p13 PATCHES

    Range
    45712..52505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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