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dsc3 protein dsc3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541990, updated on 18-Sep-2024

Summary

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Official Symbol
dsc3
Official Full Name
protein dsc3
Primary source
PomBase:SPAC20H4.02
Locus tag
SPOM_SPAC20H4.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See dsc3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2113990..2114930)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene bromodomain-containing protein Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Utp5 Neighboring gene general transcription elongation factor TFIIS Neighboring gene ATP-dependent 3'-5'-directionality DNA helicase fml2 Neighboring gene 5'-methylthioribulose-1-phosphate dehydratase Neighboring gene ncRNA Neighboring gene Gpl1-Gih35-Wdr83 complex RNA-binding subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors. Burr R, et al. J Biol Chem, 2017 Mar 31. PMID 28202541, Free PMC Article
  2. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. Raychaudhuri S, et al. J Biol Chem, 2015 Jun 5. PMID 25918164, Free PMC Article
  3. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Chong R, et al. J Biol Chem, 2013 Jul 12. PMID 23729666, Free PMC Article
  4. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. Stewart EV, et al. J Biol Chem, 2012 Jan 2. PMID 22086920, Free PMC Article
  5. Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Lloyd SJ, et al. J Biol Chem, 2013 Jul 19. PMID 23760507, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in SREBP signaling pathway EXP
Inferred from Experiment
more info
 PubMed 
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Dsc E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Dsc E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Dsc E3 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein dsc3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2113990..2114930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019053.3 → NP_593622.1  protein dsc3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593622.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HE10
    Conserved Domains (2) summary
    pfam10302
    Location:9 → 99
    DUF2407; DUF2407 ubiquitin-like domain
    pfam13373
    Location:135 → 246
    DUF2407_C; DUF2407 C-terminal domain
Nucleotide Protein
Heading Accession and Version

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