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FBXO33 F-box protein 33 [ Homo sapiens (human) ]

Gene ID: 254170, updated on 5-Apr-2020

Summary

Official Symbol
FBXO33provided by HGNC
Official Full Name
F-box protein 33provided by HGNC
Primary source
HGNC:HGNC:19833
See related
Ensembl:ENSG00000165355 MIM:609103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbx33; BMND12; c14_5247
Summary
This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 14.0), testis (RPKM 6.8) and 24 other tissues See more
Orthologs

Genomic context

See FBXO33 in Genome Data Viewer
Location:
14q21.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (39396373..39432500, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39865577..39901704, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288846 Neighboring gene MIA SH3 domain ER export factor 2 Neighboring gene uncharacterized LOC105370461 Neighboring gene uncharacterized LOC105370460 Neighboring gene coilin pseudogene 1 Neighboring gene uncharacterized LOC112267899 Neighboring gene uncharacterized LOC105370464 Neighboring gene uncharacterized LOC105370463

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027725.1 RefSeqGene

    Range
    5001..41128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_203301.3NP_976046.1  F-box only protein 33

    See identical proteins and their annotated locations for NP_976046.1

    Status: REVIEWED

    Source sequence(s)
    AI141232, AL157791, BC030611, BC053537
    Consensus CDS
    CCDS9677.1
    UniProtKB/Swiss-Prot
    Q7Z6M2
    Related
    ENSP00000298097.7, ENST00000298097.7
    Conserved Domains (1) summary
    pfam12937
    Location:69116
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    39396373..39432500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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