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mek1 meiosis-specific serine/threonine protein kinase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541604, updated on 19-Nov-2025
Official Symbol
mek1
Official Full Name
meiosis-specific serine/threonine protein kinase
Primary source
PomBase:SPAC14C4.03
Locus tag
SPOM_SPAC14C4.03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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See mek1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5231140..5232566)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene Smc5-6 complex SMC P-loop ATPase subunit Smc5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DASH complex subunit Dad3 Neighboring gene ncRNA Neighboring gene tRNA-Asp Neighboring gene ncRNA

Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The fission yeast meiotic checkpoint kinase Mek1 regulates nuclear localization of Cdc25 by phosphorylation. Pérez-Hidalgo L, et al. Cell Cycle, 2008 Dec. PMID 19029820
  2. Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Niu H, et al. Mol Cell Biol, 2007 Aug. PMID 17526735, Free PMC Article
  3. Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombe. Latypov V, et al. Mol Cell Biol, 2010 Apr. PMID 20123974, Free PMC Article
  4. S. pombe meiotic linear elements contain proteins related to synaptonemal complex components. Lorenz A, et al. J Cell Sci, 2004 Jul 1. PMID 15226405
  5. Structural insights into the recognition of phosphorylated Hop1 by Mek1. Xie C, et al. Acta Crystallogr D Struct Biol, 2018 Oct 1. PMID 30289413

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEK1 phosphorlated by Rad3 and/or Tel1 on the S12, S14, ST15 residues, and that these modifications are required for meiotic progression.
    Title: The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.
  2. Data suggest that in S. pombe meiosis, Hop1 and Mek1 possibly enhance homolog interactions to ensure wild-type level of crossover formation rather than inhibiting sister chromatid interactions.
    Title: Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombe.
  3. Mek1 acts independently of Cds1 to phosphorylate Cdc25, and this phosphorylation is required to trigger cell cycle arrest.
    Title: The fission yeast meiotic checkpoint kinase Mek1 regulates nuclear localization of Cdc25 by phosphorylation.
  4. This work demonstrates that Mek1 is activated in response to double-strand breaks by autophosphorylation of two conserved threonines, T327 and T331, in the Mek1 activation loop.
    Title: Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic recombination checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic recombination checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of initiation of premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in linear element IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
meiosis-specific serine/threonine protein kinase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5231140..5232566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020340.1 → NP_594908.1  meiosis-specific serine/threonine protein kinase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594908.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10292
    Conserved Domains (3) summary
    smart00220
    Location:164 → 421
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:39 → 141
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd05117
    Location:163 → 420
    STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
Nucleotide Protein
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