U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

csn5 COP9/signalosome complex protease subunit Csn5 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541529, updated on 19-Feb-2025
Official Symbol
csn5
Official Full Name
COP9/signalosome complex protease subunit Csn5
Primary source
PomBase:SPAC1687.13c
Locus tag
SPOM_SPAC1687.13C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table
See csn5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (926394..927626, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene rRNA methyltransferase Spb1 Neighboring gene ncRNA Neighboring gene ubiquinone biosynthesis protein Coq4 Neighboring gene ncRNA Neighboring gene calcium-binding protein Neighboring gene uncharacterized protein

Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Constitutively active Cullin-RING-Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe. Girdwood D, et al. FEBS Lett, 2012 May 21. PMID 22673520
  2. Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Zhou C, et al. Mol Cell, 2003 Apr. PMID 12718879
  3. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. Zhou C, et al. BMC Biochem, 2001. PMID 11504566, Free PMC Article
  4. CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability. Wee S, et al. Nat Cell Biol, 2005 Apr. PMID 15793566
  5. Nedd8 processing enzymes in Schizosaccharomyces pombe. O'Donoghue JE, et al. BMC Biochem, 2013 Mar 15. PMID 23496905, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The dispensable csn5 genes become essential for viability when adapter recruitment to Cul1p is compromised.
    Title: CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables deNEDDylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deNEDDylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to deNEDDylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deneddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
Preferred Names
COP9/signalosome complex protease subunit Csn5

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    926394..927626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018527.3 → NP_593131.1  COP9/signalosome complex protease subunit Csn5 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593131.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94454
    Conserved Domains (1) summary
    cd08069
    Location:24 → 266
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials