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SNX32 sorting nexin 32 [ Homo sapiens (human) ]

Gene ID: 254122, updated on 17-Jun-2019

Summary

Official Symbol
SNX32provided by HGNC
Official Full Name
sorting nexin 32provided by HGNC
Primary source
HGNC:HGNC:26423
See related
Ensembl:ENSG00000172803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX6B
Expression
Biased expression in brain (RPKM 2.1), testis (RPKM 1.0) and 7 other tissues See more
Orthologs

Genomic context

See SNX32 in Genome Data Viewer
Location:
11q13.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65833640..65855169)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65601305..65621578)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 5 subunit beta 1 Neighboring gene OVOL1 antisense RNA 1 Neighboring gene ovo like transcriptional repressor 1 Neighboring gene cofilin 1 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene EGF containing fibulin extracellular matrix protein 2 Neighboring gene cathepsin W Neighboring gene FGF1 intracellular binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30934, MGC42112, MGC57276, DKFZp761P1320

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy NAS
Non-traceable Author Statement
more info
PubMed 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sorting nexin-32
Names
sorting nexin-6B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152760.3NP_689973.2  sorting nexin-32

    See identical proteins and their annotated locations for NP_689973.2

    Status: VALIDATED

    Source sequence(s)
    BC045563, CD638068
    Consensus CDS
    CCDS8113.2
    UniProtKB/Swiss-Prot
    Q86XE0
    Related
    ENSP00000310620.6, ENST00000308342.7
    Conserved Domains (2) summary
    cd07621
    Location:180400
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
    cl02563
    Location:25163
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65833640..65855169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448419.1XP_024304187.1  sorting nexin-32 isoform X4

    Conserved Domains (2) summary
    cd07621
    Location:62239
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
    cl02563
    Location:145
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_024448418.1XP_024304186.1  sorting nexin-32 isoform X2

    Conserved Domains (2) summary
    cd06892
    Location:18157
    PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
    cd07621
    Location:174351
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
  3. XM_024448420.1XP_024304188.1  sorting nexin-32 isoform X4

    Conserved Domains (2) summary
    cd07621
    Location:62239
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
    cl02563
    Location:145
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  4. XM_017017473.1XP_016872962.1  sorting nexin-32 isoform X5

  5. XM_024448417.1XP_024304185.1  sorting nexin-32 isoform X1

    Conserved Domains (2) summary
    cd06892
    Location:24163
    PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
    cd07621
    Location:180357
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
  6. XM_006718488.4XP_006718551.1  sorting nexin-32 isoform X3

    Conserved Domains (2) summary
    cd07621
    Location:180386
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
    cl02563
    Location:25163
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RNA

  1. XR_002957137.1 RNA Sequence

  2. XR_001747822.2 RNA Sequence

  3. XR_001747821.2 RNA Sequence

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